Delpark 2 mg (Tablet)
Unit Price: ৳ 5.50 (3 x 10: ৳ 165.00)
Strip Price: ৳ 55.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct in treatment of parkinsonism
- Adjuvant therapy with levodopa
- Control of extrapyramidal disorders
- Treatment of postencephalitic, arteriosclerotic, and idiopathic parkinsonism
Description
- Exerts direct inhibitory effect on parasympathetic nervous system
- Relaxing effect on smooth musculature
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Higher affinity for M1 subtype
- Higher affinity for central muscarinic receptors in cerebral cortex
- Lower affinity for peripherally located receptors
- Possible modification of nicotinic acetylcholine receptor neurotransmission
- Enhanced dopamine release in the striatum
Dosage & Administration
- Initial low dose, gradually increased
- Individualized dosage
- Preferable administration before or after meals based on patient's reaction
- Potential need for small amounts of atropine in postencephalitic patients
- Precautions for dry mouth
- Abrupt withdrawal may result in exacerbation of symptoms or neuroleptic malignant syndrome
- Different dosages for idiopathic parkinsonism, drug-induced parkinsonism, concomitant use with levodopa, and children
- Best tolerated when divided into 3-4 doses at mealtimes
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with alcohol or other CNS depressants
- Intensification of anticholinergic effects with monoamine oxidase inhibitors and tricyclic antidepressants
- Increased risk of tardive dyskinesia during concomitant administration of anticholinergics and neuroleptics
- Possible need for reduction of levodopa dosage during concomitant therapy
Contraindications
- Hypersensitivity to trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Dilatation of the colon
- Paralytic ileus
- Psychiatric manifestations
- Cognitive dysfunctions
- Constipation
- Drowsiness
- Urinary hesitancy or retention
- Tachycardia
- Dilation of the pupil
- Increased intraocular pressure
- Choreiform movements
- Weakness
- Vomiting
- Headache
- Exacerbation of parkinsonism with abrupt treatment withdrawal
- Neuroleptic malignant syndrome
- Angle-closure glaucoma
- Paradoxical sinus bradycardia
- Dry skin
- Cycloplegia
- Hyperkinesia
- Psychosis
- Forgetfulness
- Weight loss
- Restlessness
- Chorea
- Sleep alterations
Pregnancy & Lactation
- Use only if benefit outweighs risk during pregnancy
- Caution in nursing women due to potential suppression of lactation
Precautions & Warnings
- Gonioscope evaluation prior to therapy
- Monitoring of intraocular pressures
- Possibility of angle closure with increase in intraocular pressure
- Administration caution in hot weather and concomitantly with other atropine-like drugs
- Anhidrosis management in hot environments
- Neuroleptic malignant syndrome risk with dose reduction or discontinuation
- Hyperthermia consideration in presence of anhidrosis
Overdose Effects
- Symptoms of atropine intoxication
- Neuropsychiatric signs
- Potential progression to stupor, coma, paralysis, cardiac and respiratory arrest, and death
- Gastric lavage or methods to limit absorption
- Administration of diazepam or barbiturate if CNS excitation observed
- Contraindicated phenothiazines
- Possible need for respiratory support, artificial respiration, or vasopressor agents
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Dry place
- Protection from light