Trihexy 2 mg/5 ml (Syrup)
50 ml bottle: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct in the treatment of parkinsonism
- Adjuvant therapy with levodopa
- Control of extrapyramidal disorders
- Treatment of postencephalitic parkinsonism
- Treatment of arteriosclerotic parkinsonism
- Treatment of idiopathic parkinsonism
Description
- Exerts inhibitory effect on parasympathetic nervous system
- Relaxing effect on smooth musculature
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Binds with higher affinity to M1 subtype of receptors
- Higher affinity for central muscarinic receptors in cerebral cortex
- May modify nicotinic acetylcholine receptor neurotransmission
- May lead to enhanced dopamine release in striatum
Dosage & Administration
- Initial low dose, then increased gradually
- Individualized dosage
- Dosing based on patient's age and reaction
- Can be taken before or after meals
- Recommended dosages for different forms of parkinsonism
- Concomitant use with levodopa dosage adjustments
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with CNS depressants
- Intensified anticholinergic effects with monoamine oxidase inhibitors and tricyclic antidepressants
- Possible risk of tardive dyskinesia with neuroleptics
- Levodopa dose adjustments during concomitant therapy
Contraindications
- Hypersensitivity to Trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Dilatation of the colon
- Urinary hesitancy or retention
- Tachycardia
- Drowsiness
- Exacerbation of parkinsonism with abrupt withdrawal
- Neuroleptic malignant syndrome with abrupt withdrawal
- Angle-closure glaucoma
Pregnancy & Lactation
- Not enough data in animal or human pregnancy
- Caution in nursing women due to potential excretion in human milk
- Possible suppression of lactation
Precautions & Warnings
- Gonioscope evaluation prior to therapy
- Monitoring of intraocular pressures
- Possibility of narrow angle glaucoma
- Administration caution in hot weather
- Potential for hyperthermia in patients with anhidrosis
- Risk of Neuroleptic Malignant Syndrome
Overdose Effects
- Central symptoms of atropine intoxication
- Dilated and sluggish pupils
- Warm, dry skin
- Tachycardia
- Neuropsychiatric signs
- Stupor, coma, paralysis, cardiac and respiratory arrest
- Gastric lavage for overdose treatment
- Respiratory support and artificial respiration may be necessary
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Protect from light