Parkifen 2 mg (Tablet)
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct in the treatment of all forms of parkinsonism
- Adjuvant therapy with levodopa for parkinsonism
- Control of extrapyramidal disorders caused by CNS drugs
Description
- Exerts direct inhibitory effect upon the parasympathetic nervous system
- Relaxing effect on smooth musculature
- Inhibitory effect upon parasympathetic nervous system
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Higher affinity for central muscarinic receptors in cerebral cortex
- Lower affinity for peripherally located receptors
- Modification of nicotinic acetylcholine receptor neurotransmission
- Enhanced dopamine release in the striatum
Dosage & Administration
- Individualized dosage
- Low initial dose with gradual increase
- Dose adjustment based on patient reaction
- Preferable timing in relation to meals
- Caution for patients over 60 years of age
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with alcohol or other CNS depressants
- Intensified anticholinergic effects with MAO inhibitors and tricyclic antidepressants
- Risks of drug-induced involuntary movements with concomitant use of anticholinergics and levodopa
Contraindications
- Hypersensitivity to trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Psychiatric manifestations
- Cognitive dysfunctions
- Constipation
- Drowsiness
- Urinary hesitancy or retention
- Tachycardia
- Dilation of the pupil
- Increased intraocular pressure
- Choreiform movements
- Weakness
- Vomiting
- Headache
Pregnancy & Lactation
- Use during pregnancy only if benefit outweighs risk
- Potential effects on lactation
- Caution for nursing women
Precautions & Warnings
- Gonioscope evaluation prior to therapy
- Monitoring of intraocular pressures
- Potential for angle closure and increase in intraocular pressure
- Caution in hot weather and concomitant use with other atropine-like drugs
- Risk of anhidrosis and hyperthermia
- Potential for Neuroleptic Malignant Syndrome (NMS)
Overdose Effects
- Central anticholinergic syndrome
- Recognition of peripheral signs of parasympathetic blockade
- Neuropsychiatric signs
- Symptomatic and supportive therapeutic approach
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Temperature not exceeding 30°C
- Dry place
- Protection from light