Cardivas 6.25 mg (Tablet)
Unit Price: ৳ 4.56 (5 x 10: ৳ 228.00)
Strip Price: ৳ 45.60
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | Sun pharmaceutical bangladesh ltd |
| Also available as |
Indications
- Treatment of mild, moderate, or severe heart failure
- Ischemic or cardiomyopathic origin
- Used in conjunction with digitalis, diuretics, and ACE inhibitor
- Reduces cardiovascular death and hospitalization
- Can be used in patients intolerant to ACE inhibitor
- May be used in patients not receiving digitalis, hydralazine, or nitrate therapy
Pharmacology
- Non-selective antagonism of β-adrenergic receptors
- α-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
- Used in the treatment of hypertension, angina pectoris, and congestive heart failure
Dosage & Administration
- Initial dose for hypertension: 12.5 mg once daily
- Usual dose for hypertension: 25 mg once daily
- Maximum dose for hypertension: 50 mg daily
- Initial dose for angina pectoris: 12.5 mg twice daily
- Recommended dosage for angina pectoris: 25 mg twice daily
- Maximum daily dose for elderly patients: 50 mg
- Initial dose for heart failure: 3.125 mg twice daily
- Maximum dose for heart failure: 25 mg twice daily (patients less than 85 kg) and 50 mg twice daily (patients over 85 kg)
Interaction
- Increased levels of digoxin when taken together with Cardivas
- Decreased Cmax and AUC with pretreatment of rifampin
- No alteration in the plasma protein binding of warfarin with Cardivas
- Potential potentiation of the pressor reaction with clonidine
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma or related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome without a permanent pacemaker
- Cardiogenic shock
- Severe bradycardia
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastro-intestinal disturbances
- Bradycardia
- Diminished peripheral circulation
- Peripheral edema and painful extremities
- Dry mouth and eyes
- Impotence
- Disturbances of micturition
- Influenza-like symptoms
- Angina
- Exacerbation of intermittent claudication or Raynaud's phenomenon
- Allergic skin reactions
- Exacerbation of psoriasis
- Nasal stuffiness
- Wheezing
- Depressed mood
- Sleep disturbances
- Paresthesia
- Changes in liver enzymes
- Thrombocytopenia
- Leukopenia
Pregnancy & Lactation
- Should not be used during breastfeeding
- Excreted in breast milk
- No studies in lactating women
- Should not be used during pregnancy
- Crosses the placental barrier
- No established safety and efficacy in children and neonates
Precautions & Warnings
- Take caution in hepatic impairment
- Monitor clinical status after initiation and increasing each dose
- Ensure renal function and heart failure are not deteriorating before increasing dose
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C
- Keep away from light and moisture
- Keep out of the reach of children