Cardivas 12.5 mg (Tablet)
Unit Price: ৳ 6.56 (3 x 10: ৳ 196.80)
Strip Price: ৳ 65.60
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | Sun pharmaceutical bangladesh ltd |
| Also available as |
Indications
- Treatment of mild, moderate or severe heart failure
- Treatment in conjunction with digitalis, diuretics and ACE inhibitor
- Reduction of disease progression
- Use in patients unable to tolerate an ACE inhibitor
- Use in patients not receiving digitalis, hydralazine or nitrate therapy
Pharmacology
- Non-selective antagonism of beta-adrenergic receptors
- Alpha-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
- Used in the treatment of hypertension, angina pectoris, and congestive heart failure
Dosage & Administration
- Initial dose in hypertension: 12.5 mg once daily
- Increased dose in hypertension: up to 50 mg daily
- Initial dose in angina pectoris: 12.5 mg twice daily
- Recommended dose in angina pectoris: 25 mg twice daily
- Initial dose in heart failure: 3.125 mg twice daily
- Increased dose in heart failure: up to 25 mg twice daily for patients less than 85 kg body-weight and 50 mg twice daily for patients over 85 kg
Interaction
- Interaction with digoxin
- Interaction with rifampin
- Interaction with warfarin
- Interaction with clonidine
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma or related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome without a permanent pacemaker
- Cardiogenic shock
- Severe bradycardia
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastro-intestinal disturbances
- Bradycardia
- Diminished peripheral circulation
- Peripheral edema
- Dry mouth
- Impotence
- Allergic skin reactions
- Exacerbation of psoriasis
- Nasal stuffiness
- Wheezing
- Depressed mood
- Sleep disturbances
- Paresthesia
- Changes in liver enzymes
- Thrombocytopenia
- Leukopenia
Pregnancy & Lactation
- Contraindicated during breast-feeding
- Excreted in breast milk
- Not established safety and efficacy in children
- Crosses the placental barrier
Precautions & Warnings
- Caution in hepatic impairment
- Monitor clinical status in heart failure
- Ensure renal function and heart failure are not deteriorating before increasing dose
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children