Liveric 300 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ursodeoxycholic acid |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Cholestasis (Jaundice)
- Viral Hepatitis
- Alcoholic Fatty Liver
- Primary Billiary Cirrhosis (PBC)
- Primary Sclerosing Cholangitis (PSC)
- Dissolution of Gallstones and Non-Alcoholic Steato Hepatitis (NASH)
Description
Used to reduce the cholesterol saturation of bile and to promote the dissolution of gallstones.
Pharmacology
- Decrease in secretion of cholesterol in bile
- Reduces cholesterol absorption
- Suppresses liver cholesterol synthesis
- Promotes the formation of liquid cholesterol crystal complexes
- Completely absorbed in the upper intestine
- Time to peak serum concentration varies from 30 to 150 minutes
- Rate of absorption ranges from 60-80%
- Biologic half life ranges from 3.5-5.8 days
Dosage & Administration
Dissolution of Gall stones: 8-12 mg/kg/day either as single night time dose or in divided doses. Primary Billiary Cirrhosis: 10-15 mg/kg/day in 2-4 divided doses. Acute Viral Hepatitis: 600 mg/day. Alcoholic Fatty Liver: 300 mg/day. Primary Sclerosing Cholangitis: 25-30 mg/kg/day. Dissolution of Gallstones and Non-Alcoholic Steato Hepatitis: 13-15 mg/kg/day
Interaction
Should not be used with drugs, such as oestrogenic hormones, that increase bile cholesterol. Concomitant administration with bile-acid binding drugs including antacids, charcoal and cholestyramine should be avoided.
Contraindications
- Non-functioning gall-bladder
- Calcified and pigmented gallstones
- Inflammatory bowel disease
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Gallstone opacilication
- Pruritus
Pregnancy & Lactation
Pregnancy category B. No evidence of harm has been reported in pregnancy. It has been effectively used for the treatment of cholestasis of pregnancy during the last trimester without any side effects. Problems have not been documented in humans regarding breast feeding.
Precautions & Warnings
Should be used cautiously in those with liver disease.
Therapeutic Class
Anti-gallstones drugs: Bile Acids
Storage Conditions
Store below 25°C. Protected from light and moisture. Keep the medicine out of the reach of children.