Ursolic 250 mg/5 ml (Oral Suspension)
50 ml bottle: ৳ 180.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ursodeoxycholic acid |
| Company | Drug international ltd |
| Also available as |
Title
- Ursolic
Categories
- Medicines
- Hepatobilliary Disorders
- Cholestasis Treatment
Description
Ursolic is used to reduce the cholesterol saturation of bile and to promote the dissolution of gallstones.
Indications
- Cholestasis (Jaundice)
- Viral Hepatitis
- Alcoholic Fatty Liver
- Primary Billiary Cirrhosis (PBC)
- Primary Sclerosing Cholangitis (PSC)
- Dissolution of Gallstones
- Non-Alcoholic Steato Hepatitis (NASH)
Pharmacology
- Decrease in secretion of cholesterol in bile
- Reduction in cholesterol absorption
- Suppression of liver cholesterol synthesis
- Promotes formation of liquid cholesterol crystal complexes
- Protects cholangiocytes against cytotoxicity of hydrophobic bile acids
- Stimulates hepatobilliary secretion
- Protects hepatocytes against bile acid-induced apoptosis
- Completely absorbed in the upper intestine
- Time to peak serum concentration varies from 30 to 150 minutes
- Rate of absorption ranges from 60-80%
- Biologic half life ranges from 3.5-5.8 days
Dosage & Administration
- Dissolution of Gall stones: 8-12 mg/kg/day either as single night time dose or in divided doses
- Primary Billiary Cirrhosis: 10-15 mg/kg/day in 2-4 divided doses
- Acute Viral Hepatitis: 600 mg/day
- Alcoholic Fatty Liver: 300 mg/day
- Primary Sclerosing Cholangitis: 25-30 mg/kg/day
Interaction
Ursolic should not be used with drugs, such as oestrogenic hormones, that increase bile cholesterol. Concomitant administration with bile-acid binding drugs including antacids, charcoal and cholestyramine should be avoided.
Contraindications
- Non-functioning gall-bladder
- Calcified and pigmented gallstones
- Inflammatory bowel disease
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Gallstone opacilication
- Pruritus
Pregnancy & Lactation
Pregnancy category B. No evidence of harm has been reported in pregnancy. No problems documented in humans regarding breastfeeding.
Precautions & Warnings
It should be used cautiously in those with liver disease.
Therapeutic Class
Anti-gallstones drugs: Bile Acids
Storage Conditions
Store below 25° C. Protected from light and moisture.