Stener 300 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ursodeoxycholic acid |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Cholestasis (Jaundice)
- Viral Hepatitis
- Alcoholic Fatty Liver
- Primary Billiary Cirrhosis (PBC)
- Primary Sclerosing Cholangitis (PSC)
- Dissolution of Gallstones
- Non-Alcoholic Steato Hepatitis (NASH)
Description
Stener is used to reduce the cholesterol saturation of bile and to promote the dissolution of gallstones.
Pharmacology
- Acting Agent: Ursodeoxycholic Acid
- Mechanisms:
- Reduces cholesterol absorption
- Suppresses liver cholesterol synthesis
- Does not inhibit bile acid synthesis
- Benefits:
- Protects cholangiocytes against cytotoxicity of hydrophobic bile acids
- Stimulates hepatobilliary secretion
- Protects hepatocytes against bile acid-induced apoptosis
- Bioavailability: 60-80%
- Absorption Time: 30-150 minutes
- Half-life: 3.5-5.8 days
Dosage & Administration
- Dissolution of Gall stones: 8-12 mg/kg/day
- Primary Billiary Cirrhosis: 10-15 mg/kg/day
- Acute Viral Hepatitis: 600 mg/day
- Alcoholic Fatty Liver: 300 mg/day
- Primary Sclerosing Cholangitis: 25-30 mg/kg/day
- Dissolution of Gallstones and Non-Alcoholic Steato Hepatitis: 13-15 mg/kg/day
Interaction
Stener should not be used with drugs, such as oestrogenic hormones, that increase bile cholesterol, and should be avoided with bile-acid binding drugs including antacids, charcoal, and cholestyramine.
Contraindications
- Non-functioning gall-bladder
- Calcified and pigmented gallstones
- Inflammatory bowel disease
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Gallstone opacilication
- Pruritus
Pregnancy & Lactation
Pregnancy category B. No evidence of harm has been reported in pregnancy. It has been effectively used for the treatment of cholestasis of pregnancy during the last trimester without any side effects. Problems have not been documented in humans regarding breastfeeding.
Precautions & Warnings
It should be used cautiously in those with liver disease.
Therapeutic Class
Anti-gallstones drugs: Bile Acids
Storage Conditions
Store below 25°C. Protected from light and moisture. Keep the medicine out of the reach of children.