Ursodex 300 mg (Tablet)
Unit Price: ৳ 20.00 (2 x 10: ৳ 400.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ursodeoxycholic acid |
| Company | Ibn sina pharmaceuticals ltd |
| Also available as |
Title
- Ursodex
Categories
- Hepatobilliary Disorders
- Gallstone Dissolution
- Cholestasis Treatment
- Liver Disease Therapy
- Bile Acid Therapy
Description
- Reduction of Cholesterol Saturation of Bile
- Promotion of Gallstone Dissolution
- Reduction of Cholesterol Secretion into Bile
- Increase in Bile Acid Secretion Rate
Indications
- Cholestasis (Jaundice)
- Viral Hepatitis
- Alcoholic Fatty Liver
- Primary Billiary Cirrhosis (PBC)
- Primary Sclerosing Cholangitis (PSC)
- Dissolution of Gallstones
- Non-Alcoholic Steato Hepatitis (NASH)
Pharmacology
- Decrease in Cholesterol Absorption
- Suppression of Liver Cholesterol Synthesis
- No Inhibition of Bile Acid Synthesis
- Alteration of Bile Composition
- Promotion of Liquid Cholesterol Crystal Complexes
Mode of action
- Protecting Cholangiocytes Against Cytotoxicity of Hydrophobic Bile Acids
- Stimulating Hepatobilliary Secretion
- Protecting Hepatocytes Against Bile Acid-Induced Apoptosis
- Complete Absorption in the Upper Intestine
- Time to Peak Serum Concentration Varies from 30 to 150 Minutes
Dosage administration
- Dissolution of Gallstones: 8-12 mg/kg/day
- Primary Billiary Cirrhosis: 10-15 mg/kg/day
- Acute Viral Hepatitis: 600 mg/day
- Alcoholic Fatty Liver: 300 mg/day
- Primary Sclerosing Cholangitis: 25-30 mg/kg/day
- Dissolution of Gallstones and NASH: 13-15 mg/kg/day
Interaction
- Avoidance with Oestrogenic Hormones
- Avoidance with Bile-Acid Binding Drugs (Antacids, Charcoal, Cholestyramine)
Contraindications
- Non-Functioning Gall-Bladder
- Calcified and Pigmented Gallstones
- Inflammatory Bowel Disease
Side effects
- Nausea
- Vomiting
- Diarrhoea
- Gallstone Opacilication
- Pruritus
Pregnancy lactation
- Pregnancy Category B
- No Evidence of Harm in Pregnancy
- Effective in Cholestasis of Pregnancy
- No Documented Problems in Humans Regarding Breast Feeding
Precautions warnings
- Cautious Use in Those with Liver Disease
Therapeutic class
- Anti-Gallstones Drugs
- Bile Acids
Storage conditions
- Store Below 25°C
- Protected from Light and Moisture
- Keep Out of Reach of Children