Cardovan Plus 160 mg+12.5 mg (Tablet)
Unit Price: ৳ 16.00 (3 x 10: ৳ 480.00)
Strip Price: ৳ 160.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Valsartan hydrochlorothiazide |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of hypertension
Pharmacology
- Belongs to a class of drugs called angiotensin receptor blockers (ARBs)
- Specific angiotensin II antagonist
- Orally active
- Blocks angiotensin II receptor
- Thiazide diuretic
- Affects renal tubular mechanisms of electrolyte reabsorption
- Reduces plasma volume
- Increases plasma renin activity
- Increases aldosterone secretion
- Increases urinary potassium loss
- Decreases serum potassium
Dosage & Administration
- Once daily dosage
- Maximum allowed dose of Valsartan in combination with hydrochlorothiazide
- No initial dosage adjustment for elderly patients
- Safety and effectiveness in pediatric patients not established
Interaction
- May interact with diuretics, agents increasing serum potassium, lithium salts, warfarin, digoxin, alcohol, barbiturates, narcotics, antidiabetic drugs, other antihypertensive drugs, cholestyramine and colestipol resins
Contraindications
- Contraindicated in patients hypersensitive to any component of the product
- Contraindicated in patients with anuria
- Contraindicated in patients hypersensitive to sulfonamide-derived drugs
Side Effects
- Rare side effects include headache, dizziness, fatigue, abdominal pain, cough, diarrhea, nausea, hyperkalemia, impotence, reduced renal function, allergic reactions, dyspnea, constipation, back pain, muscle cramps, rash, anxiety, insomnia, vertigo
- Hypotension may occur
Pregnancy & Lactation
- Not to be used in pregnancy
- Not known whether excreted in human milk
Precautions & Warnings
- Exercise care in patients with impaired hepatic function
- Dosage reduction or discontinuation may be required if pre-existing renal impairment
- Caution in initiating therapy in patients with heart failure and post-myocardial infarction patients
Use in Special Populations
- Usual regimens of therapy may be followed as long as the patient's creatinine clearance is >30 ml/min
- Loop diuretics preferred in patients with severe renal impairment
- Care should be taken in patients with hepatic impairment
Overdose Effects
- Manifestations of overdosage include hypotension, tachycardia, bradycardia, hypokalemia, hypochloremia, dehydration
- Excessive diuresis can lead to electrolyte depletion
- Hemodialysis removal not established
Therapeutic Class
- Combined antihypertensive preparations
Storage Conditions
- Store between 15-30°C