Valsartil Plus 160 mg+25 mg (Tablet)

Indications

• Treatment of hypertension

Pharmacology

• Belongs to class of drugs called angiotensin receptor blockers (ARBs)
• Blocks angiotensin II receptors
• Thiazide diuretic affecting renal tubular mechanisms

Dosage & Administration

• Combination therapy for uncontrolled blood pressure
• Maximum dose of Valsartan and Hydrochlorothiazide combination
• No initial dosage adjustment for elderly patients
• Not established for pediatric use

Interaction

• Potential interaction with diuretics
• Affects serum potassium levels
• Interaction with lithium salts, Warfarin, and Digoxin
• Interactions with alcohol, barbiturates, narcotics, antidiabetic drugs, and other antihypertensive drugs
• Impaired absorption in presence of anionic exchange resins

Contraindications

• Hypersensitivity to any component of the product
• Anuria
• Hypersensitivity to sulfonamide-derived drugs

Side Effects

• Rare side effects
• Common side effects: headache, dizziness, fatigue, abdominal pain, cough, diarrhea, nausea
• Potential side effects: hyperkalemia, impotency, reduced renal function, allergic reactions, dyspnea, constipation, back pain, muscle cramps, rash, anxiety, insomnia, vertigo, hypotension

Pregnancy & Lactation

• Not to be used in pregnancy
• Excretion in breast milk

Precautions & Warnings

• Care with impaired hepatic function
• Dosage adjustment or discontinuation with pre-existing renal impairment
• Caution in heart failure and myocardial infarction patients

Use in Special Populations

• Use in patients with renal impairment
• Care in patients with hepatic impairment

Overdose Effects

• Manifestations of Valsartan overdosage: hypotension, tachycardia, bradycardia, parasympathetic stimulation
• Management of Valsartan overdosage: supine positioning, intravenous infusion of normal saline
• Manifestations of Hydrochlorothiazide overdosage: electrolyte depletion, dehydration
• Potential interaction with digitalis
• Unknown removal by hemodialysis

Therapeutic Class

• Combined antihypertensive preparations

Storage Conditions

• Store between 15-30° C

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