Carvista 12.5 mg (Tablet)
Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of mild, moderate or severe heart failure
- Treatment of heart failure of ischemic or cardiomyopathic origin
- Reduction of disease progression
- Conjunction with digitalis, diuretics and ACE inhibitor
- Use in patients unable to tolerate an ACE inhibitor
- Use in patients not receiving digitalis, hydralazine or nitrate therapy
Pharmacology
- Non-selective antagonism of β-adrenergic receptors
- Appreciable α-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
- Treatment of hypertension
- Treatment of angina pectoris
Dosage & Administration
- Initial dosage for hypertension: 12.5 mg once daily
- Usual dosage for hypertension: 25 mg once daily
- Maximum dosage for hypertension: 50 mg daily
- Initial dosage for angina pectoris: 12.5 mg twice daily
- Usual dosage for angina pectoris: 25 mg twice daily
- Maximum dosage for angina pectoris: 50 mg daily
- Initial dosage for heart failure: 3.125 mg twice daily
- Usual dosage for heart failure: 25 mg twice daily
- Maximum dosage for heart failure: 25 mg twice daily (body-weight <85 kg) or 50 mg twice daily (body-weight >85 kg)
Interaction
- Interaction with digoxin
- Interaction with rifampin
- Interaction with warfarin
- Interaction with clonidine
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma or related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome without a permanent pacemaker
- Cardiogenic shock
- Severe bradycardia
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastro-intestinal disturbances
- Bradycardia
- Diminished peripheral circulation
- Peripheral oedema and painful extremities
- Dry mouth
- Dry eyes
- Eye irritation or disturbed vision
- Impotence
- Disturbances of micturition
- Influenza-like symptoms
- Angina
- AV block
- Exacerbation of intermittent claudication or Raynaud's phenomenon
- Allergic skin reactions
- Exacerbation of psoriasis
- Nasal stuffiness
- Wheezing
- Depressed mood
- Sleep disturbances
- Paresthesia
- Changes in liver enzymes
- Thrombocytopenia
- Leukopenia
Pregnancy & Lactation
- Not to be used during breast-feeding
- Animal studies showing excretion in breast milk
- Safety and efficacy not established in children
- Not to be used during pregnancy
- Crosses the placental barrier
Precautions & Warnings
- Caution in hepatic impairment
- Monitor clinical status after initiation and increasing each dose
- Ensure renal function and heart failure are not deteriorating
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children