Co-Diovan 160 mg+25 mg (Tablet)

Indications

• Treatment of hypertension

Pharmacology

• Valsartan is an angiotensin II antagonist
• Oral medication
• Hydrochlorothiazide is a thiazide diuretic
• Reduces plasma volume
• Increases plasma renin activity
• Reduces potassium levels
• Does not affect pulse rate

Dosage & Administration

• Combined once daily dosing
• Maximum allowed dose of Valsartan and Hydrochlorothiazide combination
• No initial dosage adjustment for elderly patients
• Safety and effectiveness not established in pediatric patients

Interaction

• Potential interactions with diuretics
• Potential interactions with agents increasing serum potassium
• Potential interactions with lithium salts
• Potential interactions with other drugs
• Additive effects when administered concurrently with certain drugs

Contraindications

• Hypersensitivity to any component of the product
• Anuria or hypersensitivity to sulfonamide-derived drugs

Side Effects

• Headache
• Dizziness
• Fatigue
• Abdominal pain
• Cough
• Diarrhea
• Nausea
• Hyperkalemia
• Impotency
• Reduced renal function
• Allergic reactions
• Dyspnea
• Constipation
• Back pain
• Muscle cramps
• Rash
• Anxiety
• Insomnia
• Vertigo
• Hypotension

Pregnancy & Lactation

• Not to be used in pregnancy
• Excretion in breast milk

Precautions & Warnings

• Impaired hepatic function
• Impaired renal function
• Caution in patients with heart failure and myocardial infarction

Use in Special Populations

• Use in patients with renal impairment
• Use in patients with hepatic impairment

Overdose Effects

• Manifestations of Valsartan overdosage
• Manifestations of Hydrochlorothiazide overdosage
• Treatment for excessive hypotension
• Signs and symptoms caused by electrolyte depletion

Therapeutic Class

• Combined antihypertensive preparations

Storage Conditions

• Store between 15-30°C

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