Cavelon 6.25 mg (Tablet)
Unit Price: ৳ 3.05 (5 x 10: ৳ 152.50)
Strip Price: ৳ 30.50
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | Drug international ltd |
| Also available as |
Indications
- Treatment of mild heart failure
- Treatment of moderate heart failure
- Treatment of severe heart failure
- Ischemic heart failure treatment
- Cardiomyopathic heart failure treatment
- Reduction of disease progression
- Reduction of cardiovascular death
- Reduction of cardiovascular hospitalization
- Reduction of need to adjust heart failure medications
- Use in patients unable to tolerate ACE inhibitor
- Use in patients not receiving digitalis, hydralazine or nitrate therapy
Pharmacology
- Non-selective antagonism of beta-adrenergic receptors
- Alpha-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of free oxidant radicals
- Used in treatment of hypertension
- Used in treatment of angina pectoris
- Used in treatment of congestive heart failure
Dosage & Administration
- Initial dose of 12.5 mg once daily for hypertension
- Usual dose of 25 mg once daily for hypertension
- Maximum dose of 50 mg daily for hypertension
- Initial dose of 12.5 mg twice daily for angina pectoris
- Recommended dose of 25 mg twice daily for angina pectoris
- Maximum daily dose of 50 mg for angina pectoris
- Initial dose of 3.125 mg twice daily for heart failure
- Maximum dose of 25 mg twice daily for patients less than 85 kg body weight
- Maximum dose of 50 mg twice daily for patients over 85 kg body weight
Interaction
- Increased levels of digoxin when taken concomitantly
- Adverse effects with concomitant use of Cavelon and digoxin
- Decrease in Cmax and AUC with pretreatment with rifampin
- No alteration in plasma protein binding of warfarin
- Potentiation of pressor reaction with sudden withdrawal of clonidine
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma or related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome without permanent pacemaker
- Cardiogenic shock
- Severe bradycardia
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastrointestinal disturbances
- Bradycardia
- Diminished peripheral circulation
- Peripheral edema
- Painful extremities
- Dry mouth
- Dry eyes
- Eye irritation
- Disturbed vision
- Impotence
- Disturbances of micturition
- Influenza-like symptoms
- Angina
- Exacerbation of intermittent claudication
- Raynaud's phenomenon
- Allergic skin reactions
- Exacerbation of psoriasis
- Nasal stuffiness
- Wheezing
- Depressed mood
- Sleep disturbances
- Paresthesia
- Changes in liver enzymes
- Thrombocytopenia
- Leukopenia
Pregnancy & Lactation
- Contraindicated during breastfeeding
- Excreted in breast milk
- Safety and efficacy not established in children
- Contraindicated during pregnancy
- Crosses the placental barrier
Precautions & Warnings
- Take caution in hepatic impairment
- Monitor clinical status after initiation and dose increases
- Ensure renal function and heart failure are not deteriorating
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C temperature
- Away from light and moisture
- Keep out of the reach of children