Aptin M 50 mg+500 mg (Tablet)
Unit Price: ৳ 22.00 (3 x 10: ৳ 660.00)
Strip Price: ৳ 220.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Vildagliptin metformin hydrochloride |
| Company | Aci limited |
| Also available as |
Indications
- Adjunct to diet and exercises
- Improves glycaemic control
- Type 2 diabetes mellitus
Pharmacology
- Inhibition of DPP-4 enzyme
- Increase in incretin hormones GLP-1 and GIP
- Insulin secretion from pancreatic beta cell
- Decrease in glucagon secretion from alpha cell
- Decreased hepatic glucose production
Dosage & Administration
- Initiation based on current Metformin dose
- Twice daily administration
- May be taken with food
- No clinical experience in triple combination with other antidiabetic agents
Interaction
- No clinically relevant pharmacokinetic interaction observed
- Low potential for drug interactions
- Not likely to interact with CYP 450 enzymes
- No clinically relevant interactions with other oral antidiabetics
- Effects of co-administration with furosemide, nifedipine, and glyburide on Metformin
Contraindications
- Known hypersensitivity to Vildagliptin or Metformin Hydrochloride
- Renal disease or dysfunction
- Acute myocardial infarction
- Septicaemia
- Congestive heart failure
- Acute or chronic metabolic acidosis
- Use during radiologic studies with intravascular administration
Side Effects
- Headache
- Tremor
- Dizziness
- Nausea
- Hypoglycemia
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Not recommended during pregnancy unless potential benefit justifies the potential risk to the foetus
- No studies conducted regarding excretion in human milk
- Not recommended for breastfeeding women
Precautions & Warnings
- Occurrence of Lactic acidosis due to Metformin accumulation
- Monitoring of serum creatinine in patients
- Special caution in elderly patients
- Recommendation for Liver Function Tests (LFTs) monitoring
- Caution in patients with jaundice or signs of liver dysfunction
- Discontinuation before elective surgery with general anaesthesia
Use in Special Populations
- Not recommended for pediatric patients
- Monitoring of renal function in elderly patients
- Use only in elderly patients with normal renal function
- Not recommended in patients with renal or hepatic impairment
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children