Edvila-M 50 mg+500 mg (Tablet)
Unit Price: ৳ 22.00 (3 x 7: ৳ 462.00)
Strip Price: ৳ 154.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Vildagliptin metformin hydrochloride |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct to diet and exercises
- Improves glycaemic control
- Type 2 diabetes mellitus
- Not adequately controlled on Metformin Hydrochloride
- Not adequately controlled on Vildagliptin alone
- Combination treatment
Pharmacology
- Inhibition of DPP-4
- Increase in insulin secretion
- Decrease in glucagon secretion
- Lowering plasma glucose
- Mechanism of action different from sulfonylureas
Dosage & Administration
- Initiation based on current Metformin dose
- Twice daily administration
- Recommendation to take with food to reduce gastrointestinal symptoms
Interaction
- No clinically relevant pharmacokinetic interactions
- Low potential for drug interactions
- Not a cytochrome P (CYP) 450 enzyme substrate
- No interactions with other oral antidiabetics
- Interaction with furosemide, nifedipine and glyburide
Contraindications
- Known hypersensitivity to Vildagliptin or Metformin Hydrochloride
- Renal disease or dysfunction
- Acute myocardial infarction
- Septicaemia
- Congestive heart failure
- Acute or chronic metabolic acidosis
- Temporary discontinuation for radiologic studies with iodinated contrast materials
Side Effects
- Headache
- Tremor
- Dizziness
- Nausea
- Hypoglycemia
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Potential risk to the fetus
- Not recommended during pregnancy
- Unknown excretion in human milk
- Not recommended for breastfeeding women
Precautions & Warnings
- Lactic acidosis risk due to Metformin accumulation
- Monitoring of serum creatinine in patients with renal function
- Special caution in elderly patients
- Monitoring of Liver Function Tests (LFTs)
- Jaundice or signs of liver dysfunction
- Discontinuation before elective surgery with general anesthesia
Use in Special Populations
- Not recommended for pediatric patients
- Monitoring of renal function in elderly patients
- Contraindicated in patients with renal failure or dysfunction
- Not recommended in patients with hepatic impairment
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Dry place
- Away from light and heat
- Keep out of the reach of children