Dilapress 6.25 mg (Tablet)
Unit Price: ৳ 3.00 (3 x 10: ৳ 90.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of heart failure
- Reduction of disease progression
- Adjunct with digitalis, diuretics, and ACE inhibitor
- Use in patients unable to tolerate ACE inhibitor
- Use in patients not receiving digitalis, hydralazine or nitrate therapy
Pharmacology
- Non-selective antagonism of β-adrenergic receptors
- Alpha-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
- Treatment of hypertension
- Treatment of angina pectoris
- Treatment of congestive heart failure
Dosage & Administration
- Initial dose for hypertension: 12.5 mg once daily
- Usual dose for hypertension: 25 mg once daily
- Initial dose for angina pectoris: 12.5 mg twice daily
- Usual dose for angina pectoris: 25 mg twice daily
- Initial dose for heart failure: 3.125 mg twice daily
- Usual dose for heart failure: 25 mg twice daily
- Maximum dosage for elderly patients: 50 mg daily
Interaction
- Increased monitoring of digoxin recommended
- Rifampin decreases Cmax and AUC
- No alteration of warfarin's plasma protein binding
- Potentiation of pressor reaction by clonidine withdrawal
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma or related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome (unless a permanent pacemaker is in place)
- Cardiogenic shock
- Severe bradycardia
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastrointestinal disturbances
- Bradycardia
- Peripheral oedema
- Dry mouth
- Impotence
- Allergic skin reactions
- Exacerbation of psoriasis
- Nasal stuffiness
- Depressed mood
- Changes in liver enzymes
- Thrombocytopenia
- Leukopenia
Pregnancy & Lactation
- Not recommended during breastfeeding
- Not recommended during pregnancy
- Excretion in breast milk
- Crosses placental barrier
- No established safety and efficacy in children or neonates
Precautions & Warnings
- Caution in hepatic impairment
- Monitoring of clinical status in heart failure
- Monitoring renal function
- Monitoring after initiation and dose increase
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C
- Away from light & moisture
- Keep out of the reach of children