SB-Metvilda 50 mg+850 mg (Tablet)
Unit Price: ৳ 17.00 (20's pack: ৳ 340.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Vildagliptin metformin hydrochloride |
| Company | Sunman birdem pharma ltd |
| Also available as |
Indications
- Adjunct to diet and exercise for type 2 diabetes mellitus
- Improves glycaemic control
- Not adequately controlled on Metformin Hydrochloride or Vildagliptin alone
- Already treated with the combination of Vildagliptin and Metformin Hydrochloride
Pharmacology
- Inhibits DPP-4 (Dipeptidyl peptidase-4)
- Inhibition of incretin hormone degradation
- Increases insulin secretion
- Decreases glucagon secretion
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Initiated at twice daily
- Morning and evening dosing
- May be switched from separate tablets containing same doses of each component
- Higher doses not recommended
- Should be taken with or just after food
Interaction
- No clinically relevant pharmacokinetic interaction observed
- Low potential for drug interactions
- Not likely to interact with CYP 450 enzymes
- No clinically relevant interactions with other oral antidiabetics
- Some medications increase Cmax and blood AUC of Metformin
Contraindications
- Known hypersensitivity to Vildagliptin or Metformin Hydrochloride
- Renal disease or dysfunction
- Acute myocardial infarction
- Septicaemia
- Congestive heart failure
- Acute or chronic metabolic acidosis
- Use during radiologic studies with intravascular administration of iodinated contrast materials
Side Effects
- Headache
- Tremor
- Dizziness
- Nausea
- Hypoglycemia
Pregnancy & Lactation
- No adequate and well controlled studies in pregnant women
- Not recommended during pregnancy
- Not known whether excreted in human milk
Precautions & Warnings
- Lactic acidosis can occur
- Serum creatinine monitoring
- Special caution in elderly patients
- Liver Function Tests (LFTs) monitoring
- Caution in patients with liver dysfunction
- Discontinue 48 hours before elective surgery with general anaesthesia
Use in Special Populations
- Not recommended for use in children below 18 years of age
- Elderly patients should have renal function monitored regularly
- Not recommended for use in patients with renal failure
- Not recommended in patients with hepatic impairment
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children