Velvin 10 mg/10 ml (Injection)

10 mg vial: ৳ 850.00

Medicine Details

Indications

  • Treatment of Hodgkin’s disease
  • Treatment of advanced testicular carcinoma
  • Palliative treatment of lymphocytic lymphoma
  • Treatment of choriocarcinoma
  • Treatment of carcinoma of the breast

Pharmacology

  • M phase specific
  • Binds to microtubular proteins
  • Arrests mitosis at metaphase
  • Blocks glutamic acid utilization
  • Inhibits purine synthesis

Dosage & Administration

  • Initial adult dosage: 3.7 mg/m^2
  • Usual adult dosage: 5.5-7.4 mg/m^2 per week
  • Initial child dosage: 2.5 mg/m^2 of BSA
  • Max weekly dose for adults: 18.5 mg/m^2
  • Max weekly dose for children: 12.5 mg/m^2
  • Duration of maintenance therapy depends on disease state and combination with other antineoplastic agents

Interaction

  • Possible increase in vinblastine levels with aprepitant
  • Reduced vinblastine metabolism with miconazole
  • Variable interactions with phenytoin
  • Additive myelotoxicity with zidovudine
  • Concurrent admin of vinblastine with CYP3A inhibitors may cause earlier onset and increased severity of side effects
  • Reduced immune response with vaccines

Contraindications

  • Severe bone marrow suppression
  • Presence of bacterial infection
  • Malignant cell infiltration of bone marrow
  • Inj into extremity with poor circulation
  • Porphyria
  • Granulocytopenia
  • Elderly with cachexia or extreme skin ulcerations
  • Pregnancy
  • Lactation
  • Intrathecal use

Side Effects

  • Alopecia
  • Constipation
  • Malaise
  • Stomatitis
  • Hypertension
  • Neurotoxicity
  • Ischaemic cardiac toxicity
  • Nausea
  • Vomiting
  • GI bleed
  • Necrosis
  • Cellulitis

Pregnancy & Lactation

  • Category D: Positive evidence of human fetal risk

Precautions & Warnings

  • Hepatic impairment
  • Neurotoxicity
  • Ischemic heart disease
  • Pulmonary dysfunction
  • Extravasation precautions
  • Routine prophylaxis against constipation
  • Nadir in leukocyte count

Use in Special Populations

  • Hepatic Impairment: Reduce dose by 50% if serum bilirubin >3 mg/100ml

Overdose Effects

  • Symptoms: Severe bone marrow suppression and extensions of usual side effects
  • Management: Supportive treatment, monitor CV system and daily blood counts

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Store at 2-8°C

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