Vinstin 2 mg/vial (Injection)
2 mg vial: ৳ 400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Vincristine sulfate |
| Company | Drug international ltd |
Indications
- Acute leukemia
- Hodgkin's disease
- Non-Hodgkin's malignant lymphomas
- Rhabdomyosarcoma
- Neuroblastoma
- Wilms'tumor
Pharmacology
- Alkaloid obtained from the periwinkle plant
- White or slightly yellow, hygroscopic, amorphous or crystalline powder
- Freely soluble in water
- Slightly soluble in alcohol
- Triphasic serum decay pattern
- Liver as the major excretory organ
- 80% excreted in faeces
- 10-20% excreted in urine
- Over 90% distributed from blood into tissue within 15-30 minutes
- Tightly bound in tissue
Dosage & Administration
- Given intravenously at weekly intervals
- Fatal if given intrathecally
- Usual dose for adults: 1.4 mg/m2
- Usual dose for children: 1.5-2 mg/m2
- Initial dose for children weighing 10 kg or less: 0.05 mg/kg once a week
- Should not be administered to patients receiving radiation therapy through ports including the liver
- When used with L-asparaginase, given 12-24 hours prior to minimize toxicity
- Injection into a vein or tubing of an i.g. infusion
- Injection completed in about 1 minute
- May be further diluted with 0.9% sodium chloride injection or 0.5% dextrose injection
Interaction
- Allopurinol may increase bone-marrow depression incidence
- Neurotoxicity may be additive with asparaginase, isoniazid, and other drugs acting on the peripheral nervous system
- Concurrent use with doxorubicin and prednisone may produce increased myelosuppression
- Increases cellular uptake of methotrexate by malignant cells
Contraindications
- Demyelinating form of Charcot-Marie-Tooth Syndrome
- Should not be administered to patients receiving radiation therapy through ports including the liver
- Known hypersensitivity to vinca alkaloids or mannitol
Side Effects
- Adverse reactions are reversible and related to dosage
- Most common adverse reaction is hair loss
- Neuromuscular adverse reactions are most troublesome
- Rare cases of allergic-type reactions
- Autonomic toxicity such as constipation and paralytic ileus
- Genitourinary hyperuricaemia
- Hypertension and hypotension
- Neurologic adverse reactions
- Other adverse reactions including fever, headache, defective sweating, myoclonic jerks, abnormal Vasalva response, impotence, diminished libido, and weight loss
Pregnancy & Lactation
- Pregnancy Category D
- No adequate and well-controlled studies in pregnant women
- Reported to be found in human milk
- Patients receiving Vincristine should not breastfeed
Precautions & Warnings
- Extreme care in calculating and administering the dose
- Injection leakage into surrounding tissue should be discontinued immediately
- Only to be used by physicians experienced in cytotoxic chemotherapy
- Very irritating and should not be given intramuscularly, subcutaneously, or intrathecally
- Vesicant causing severe local reaction on extravasation
- Leucopenia is less likely following therapy with vincristine
- Caution in patients with a history of gout or urate renal stones
- Vincristine penetrates the blood-brain barrier poorly
- Acute shortness of breath and severe bronchospasm reported
- Not to be readministered
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Store in a refrigerator at 2°C - 8°C
- Do not freeze
- Protect from light
- Keep out of the reach of children