Dilgard 6.25 mg (Tablet)
Unit Price: ৳ 3.02 (3 x 10: ৳ 90.45)
Strip Price: ৳ 30.15
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of mild, moderate, or severe heart failure
- Reduction of progression of disease
- Treatment of heart failure of ischemic or cardiomyopathic origin
- Conjunction with digitalis, diuretics, and ACE inhibitor
Pharmacology
- Non-selective antagonism of adrenergic receptors
- Alpha-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
- Treatment of hypertension, angina pectoris, and congestive heart failure
Dosage & Administration
- Initial dose for hypertension: 12.5 mg once daily
- Usual dose for hypertension: 25 mg once daily
- Maximum dose for hypertension: 50 mg daily
- Initial dose for angina pectoris: 12.5 mg twice daily
- Recommended dose for angina pectoris: 25 mg twice daily
- Maximum daily dose for angina pectoris: 50 mg
- Initial dose for heart failure: 3.125 mg twice daily
- Maximum dose for heart failure: 25 mg twice daily for patients less than 85 kg
Interaction
- Increased levels of digoxin when taken together with Dilgard
- Significant decrease in Cmax and AUC with rifampin
- No alteration in the plasma protein binding of warfarin
- Potentiation of the pressor reaction with clonidine
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma or related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome without a permanent pacemaker
- Cardiogenic shock or severe bradycardia
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastro-intestinal disturbances
- Bradycardia
- Peripheral oedema
- Dry mouth
- Impotence
- Exacerbation of psoriasis
Pregnancy & Lactation
- Not recommended during breast-feeding
- Not recommended during pregnancy
- Excretion in breast milk
- Crosses the placental barrier
Precautions & Warnings
- Caution in hepatic impairment
- Monitor clinical status for 2-3 hours after initiation
- Monitor after increasing each dose
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C temperature
- Keep away from light & moisture
- Keep out of the reach of children