Dilol 6.25 mg (Tablet)
Unit Price: ৳ 3.00 (100's pack: ৳ 300.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | Mystic pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of mild, moderate, or severe heart failure
- Reduction of cardiovascular death
- Reduction of cardiovascular hospitalization
- Adjunct to digitalis, diuretics, and ACE inhibitor
- Use in patients unable to tolerate an ACE inhibitor
- Use in patients not receiving digitalis, hydralazine, or nitrate therapy
Pharmacology
- Non-selective antagonism of β-adrenergic receptors
- Alpha-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
- Treatment of hypertension
- Treatment of angina pectoris
- Treatment of congestive heart failure
Dosage & Administration
- Initial dose of 12.5 mg once daily for hypertension
- Initial dose of 12.5 mg twice daily for angina pectoris
- Initial dose of 3.125 mg twice daily for heart failure
- Maximum daily dose of 50 mg for angina pectoris
- Maximum daily dose of 25 mg for heart failure in patients <85 kg
- Maximum daily dose of 50 mg for heart failure in patients >85 kg
Interaction
- Increased levels of digoxin when taken together
- Decrease in Cmax and AUC with rifampin pretreatment
- No alteration in plasma protein binding of warfarin
- Potentiation of the pressor reaction with clonidine withdrawal
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma or related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome without permanent pacemaker
- Cardiogenic shock
- Severe bradycardia
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastro-intestinal disturbances
- Bradycardia
- Diminished peripheral circulation
- Peripheral edema
- Painful extremities
- Dry mouth
- Dry eyes
- Impotence
- Disturbances of micturition
- Influenza-like symptoms
- Angina
- AV block
- Exacerbation of intermittent claudication
- Exacerbation of Raynaud's phenomenon
- Allergic skin reactions
- Exacerbation of psoriasis
- Nasal stuffiness
- Wheezing
- Depressed mood
- Sleep disturbances
- Paresthesia
- Changes in liver enzymes
- Thrombocytopenia
- Leukopenia
Pregnancy & Lactation
- Not to be used during breastfeeding
- No established safety and efficacy in children
- Not to be used during pregnancy
- Crosses the placental barrier
- No information on safety and efficacy in neonates
Precautions & Warnings
- Caution in hepatic impairment
- Monitoring of clinical status after initiation and dose increase
- Assessment of renal function and heart failure status before increasing dose
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C temperature
- Away from light and moisture
- Keep out of the reach of children