Dilol 12.5 mg (Tablet)
Unit Price: ৳ 5.00 (50's pack: ৳ 250.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | Mystic pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of mild, moderate or severe heart failure
- Reduction of disease progression
- Use in patients unable to tolerate an ACE inhibitor
- Use in patients not receiving digitalis, hydralazine or nitrate therapy
Pharmacology
- Non-selective antagonism of β-adrenergic receptors
- α-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
- Treatment of hypertension
- Treatment of angina pectoris
- Treatment of congestive heart failure
Dosage & Administration
- Initial dose of 12.5 mg once daily for hypertension
- Initial dose of 12.5 mg twice daily for angina pectoris
- Initial dose of 3.125 mg twice daily for heart failure
- Maximum daily dose of 50 mg for angina pectoris in elderly patients
- Maximum doses for heart failure based on body-weight
Interaction
- Significantly increased levels of digoxin when taken together
- 60% decrease in Cmax and AUC with rifampin
- No alteration of in vitro plasma protein binding of warfarin
- Potentiation of the pressor reaction by clonidine withdrawal
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma or related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome without a permanent pacemaker
- Cardiogenic shock or severe bradycardia
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastro-intestinal disturbances
- Bradycardia
- Diminished peripheral circulation
- Peripheral oedema
- Painful extremities
- Dry mouth
- Dry eyes
- Eye irritation
- Impotence
- Disturbances of micturition
- Influenza-like symptoms
- Angina
- AV block
- Exacerbation of intermittent claudication or Raynaud's phenomenon
- Allergic skin reactions
- Exacerbation of psoriasis
- Nasal stuffiness
- Wheezing
- Depressed mood
- Sleep disturbances
- Paresthesia
- Heart failure
- Changes in liver enzymes
- Thrombocytopenia
- Leukopenia
Pregnancy & Lactation
- Not to be used during breastfeeding
- No safety and efficacy studies in children
- Not to be used during pregnancy
- Crosses the placental barrier
- No information on safety and efficacy in neonates
Precautions & Warnings
- Caution in hepatic impairment
- Monitor clinical status for 2-3 hours after initiation and dose increases
- Ensure renal function and heart failure are not deteriorating before increasing dose
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C
- Away from light & moisture
- Keep out of the reach of children