Farin 5 mg (Tablet)

Indications

• Prophylaxis and/or treatment of thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement
• Reduction of the risk of death, recurrent myocardial infarction, and thromboembolic events such as stroke or systemic embolization after myocardial infarction
• Prophylaxis and treatment of venous thrombosis and pulmonary embolism
• Treatment of transient ischaemic attacks

Description

• Anticoagulant that inhibits the synthesis of vitamin K dependent clotting factors
• Acts by inhibiting the synthesis of Factors II, VII, IX, and X
• Anticoagulant effect occurs within 24 hours
• Maximum effect reached in 36-48 hours
• Effect is maintained for 48 hours or more after administration is stopped

Pharmacology

• Warfarin is a vitamin K antagonist
• Inhibits the production of vitamin K by vitamin K epoxide reductase
• Inhibition interrupts the coagulation cascade
• Results in a hypercoagulable state for a short time
• Vitamin K must be supplied to reverse the anticoagulation

Dosage & Administration

• Usual adult induction dose of warfarin is 10 mg daily for 2 days
• Subsequent maintenance dose is usually 3 to 9 mg daily
• Initial dose for children is usually 0.1 mg.kg-1.d-1
• Regular prothrombin time tests are essential
• Baseline prothrombin time should be determined before the initial dose

Interaction

• Oral anticoagulants have a greater potential for clinically significant drug interactions

Contraindications

• Not to be administered in actual or potential hemorrhagic conditions
• Severe hepatic or renal disease
• Pregnancy
• Known hypersensitivity to warfarin
• Bacterial endocarditis

Side Effects

• Principal adverse effect is hemorrhage
• Other adverse reactions include nausea, vomiting, diarrhea, hypersensitivity, rash, alopecia
• Unexplained drop in haematocrit, "purple toes", skin necrosis, jaundice, and hepatic dysfunction

Pregnancy & Lactation

• Contraindicated in the first trimester of pregnancy
• Should not be used in women who are or may become pregnant
• Passes through the placental barrier and may cause fatal hemorrhage to the fetus
• Appears in the milk of nursing mothers in an inactive form

Precautions & Warnings

• Periodic determination of prothrombin time (PT)/international normalized ratio (INR) is essential
• Numerous factors may influence response to anticoagulants, including travel, changes in diet, environment, physical state and medication
• Elderly subjects may exaggerate the effects of warfarin
• Careful additional laboratory control is necessary when changing from one formulation to another

Overdose Effects

• Excessive depression of the coagulation activity can be corrected by temporary withdrawal of warfarin
• Accompanied, if necessary, by infusion of fresh-frozen plasma or whole blood
• Vitamin K may be required to supplement specific treatment

Therapeutic Class

• Anti-coagulants
• Oral Anti-coagulants

Storage Conditions

• Do not store above 30°C
• Keep away from light and out of the reach of children

Related Brands

• Warin 5 mg (Tablet) - incepta-pharmaceuticals-ltd