Warin 2 mg (Tablet)
Unit Price: ৳ 2.00 (10 x 10: ৳ 200.00)
Strip Price: ৳ 20.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Warfarin sodium |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Title and Categories
- Warfarin
- Anticoagulant
- Oral Medication
- Thromboembolic Complications
- Atrial Fibrillation
- Cardiac Valve Replacement
Dimensions
- N/A
Color Options
- N/A
Functions
- Prophylaxis and treatment of thromboembolic complications
- Reduction of risk of death and myocardial infarction
- Anticoagulant effect through inhibition of clotting factors synthesis
Materials
- Active ingredient: Warfarin
- Inactive ingredients: Varies by formulation
Technical Specifications
- Antagonist of vitamin K
- Inhibition of Vitamin K epoxide reductase
- Maximum anticoagulant effect within 36-48 hours
- Half-lives of factor degradation
Design Elements
- N/A
Usability Features
- Contraindications for hemorrhagic conditions, hepatic or renal disease, pregnancy, known hypersensitivity, and bacterial endocarditis
- Dosing for adults and children
- Monitoring of prothrombin time (PT)/international normalized ratio (INR)
- Reversal of anticoagulation by vitamin K
Interaction
- Potential for clinically significant drug interactions
- Prevention of drug intake or withdrawal without physician advice
Indications
- Prophylaxis and/or treatment of thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement
- Reduction of risk of death, recurrent myocardial infarction, stroke or systemic embolization after myocardial infarction
- Prophylaxis and treatment of venous thrombosis, pulmonary embolism, and transient ischaemic attacks
Dosage & Administration
- Usual adult induction dose of warfarin: 10 mg daily for 2 days
- Subsequent maintenance dose depends on prothrombin time reported as INR
- Omitted maintenance dose if prothrombin time is excessively prolonged
- Safety and efficacy for children <18 years old not established
Contraindications
- Hemorrhagic conditions, uncontrolled hypertension, severe hepatic or renal disease, pregnancy, hypersensitivity to warfarin, bacterial endocarditis
- Caution within 24 hours following surgery or labor
Side Effects
- Hemorrhage
- Nausea
- Vomiting
- Diarrhea
- Hypersensitivity
- Rash
- Alopecia
- Unexplained drop in haematocrit
- Purple toes
- Skin necrosis
- Jaundice
- Hepatic dysfunction
Pregnancy & Lactation
- Contraindicated in the first trimester of pregnancy
- Passes through placental barrier
- Appears in the milk of nursing mothers in an inactive form
Precautions & Warnings
- Periodic determination of prothrombin time (PT)/international normalized ratio (INR)
- Influence of factors on patient's response to anticoagulants
- Exaggerating and mitigating factors for dosage adjustment
- Laboratory control when changing from one formulation to another
Overdose Effects
- Correction of excessive depression of coagulation activity by temporary withdrawal of warfarin
- Supplemental treatment with co-factor concentrates and vitamin K
Therapeutic Class
- Anti-coagulants
- Oral Anti-coagulants
Storage Conditions
- Storage not above 30°C
- Keep away from light and out of the reach of children