Unifarin 1 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Warfarin sodium |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Prophylaxis and/or treatment of thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement
- Indicated to reduce the risk of death, recurrent myocardial infarction, and thromboembolic events such as stroke or systemic embolization after myocardial infarction
- Prophylaxis and treatment of venous thrombosis and pulmonary embolism
- Transient ischaemic attacks
Description
Anticoagulant that acts by inhibiting the synthesis of vitamin K dependent clotting factors
Pharmacology
Acts as a vitamin K antagonist; inhibits the production of vitamin K by vitamin K epoxide reductase
Dosage & Administration
- Adults: Usual induction dose: 10 mg daily for 2 days, maintenance dose varies based on prothrombin time
- Children: Initial dose usually 0.1 mg.kg-1.d-1, adjusted subsequently to aim for an INR range the same as in adults
Interaction
Has potential for clinically significant drug interactions; patients should be warned and instructed against making changes without medical advice
Contraindications
- Actual or potential hemorrhagic conditions
- Severe hepatic or renal disease
- Pregnancy
- Known hypersensitivity to warfarin
- Bacterial endocarditis
Side Effects
- Hemorrhage
- Nausea
- Vomiting
- Diarrhea
- Hypersensitivity
- Rash
- Alopecia
- Unexplained drop in haematocrit
- "Purple toes"
- Skin necrosis
- Jaundice
- Hepatic dysfunction
Pregnancy & Lactation
Contraindicated in the first trimester of pregnancy, passes through placental barrier, and may cause fatal hemorrhage to the fetus
Precautions & Warnings
Periodic determination of prothrombin time (PT)/international normalized ratio (INR) is essential; numerous factors may influence patient's response to anticoagulants
Overdose Effects
Excessive depression of coagulation activity can be corrected by temporary withdrawal of warfarin and infusion of fresh-frozen plasma or whole blood; vitamin K may be required to supplement specific treatment with co-factor concentrates
Therapeutic Class
Anti-coagulants, Oral Anti-coagulants
Storage Conditions
Do not store above 30°C; keep away from light and out of the reach of children