Unifarin 2 mg (Tablet)
Unit Price: ৳ 2.00 (10 x 10: ৳ 200.00)
Strip Price: ৳ 20.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Warfarin sodium |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Prophylaxis and/or treatment of thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement
- Reduction of risk of death, recurrent myocardial infarction, stroke, or systemic embolization after myocardial infarction
- Prophylaxis and treatment of venous thrombosis and pulmonary embolism
- Treatment of transient ischaemic attacks
Description
- Anticoagulant that inhibits the synthesis of vitamin K dependent clotting factors
- Acts by inhibiting the production of vitamin K by vitamin K epoxide reductase
- Anticoagulant effect occurs within 24 hours after administration
Pharmacology
- Acts as a vitamin K antagonist
- Inhibits the production of vitamin K by vitamin K epoxide reductase
- Inhibits the synthesis of vitamin K dependent clotting factors
DosageAdministration
- Usual adult induction dose of warfarin is 10 mg daily for 2 days
- Daily maintenance dose of warfarin is usually 3 to 9 mg
- Maintenance dosage adjusted according to regular prothrombin time tests
Interaction
- Oral anticoagulants have a greater potential for clinically significant drug interactions
- Patients should be warned about potential hazards and instructed against taking or withdrawing any drug without the advice of a physician
Contraindications
- Cannot be administered in cases of actual or potential hemorrhagic conditions
- Not suitable for patients with severe hepatic or renal disease
- Contraindicated in pregnancy and known hypersensitivity to warfarin
- Not to be used within 24 hours following surgery or labor
SideEffects
- Principal adverse effect is hemorrhage
- Other adverse reactions include nausea, vomiting, diarrhea, hypersensitivity, rash, alopecia, unexplained drop in hematocrit, 'purple toes', skin necrosis, jaundice, and hepatic dysfunction
PregnancyLactation
- Contraindicated in the first trimester of pregnancy due to risk of teratogenicity
- Should not be used in women who are or may become pregnant as it may cause fatal hemorrhage to the fetus
- Appears in the milk of nursing mothers in an inactive form
PrecautionsWarnings
- Periodic determination of prothrombin time (PT)/international normalized ratio (INR) is essential
- Response to anticoagulants may be influenced by travel, diet, environment, physical state, and medication
- Good practice to monitor the patient's response with additional PT/INR determination after discharge from the hospital, and whenever other medications are initiated, discontinued, or taken irregularly
OverdoseEffects
- Excessive depression of coagulation activity can be corrected by temporary withdrawal of warfarin
- Vitamin K may be required to supplement specific treatment with co-factor concentrates
TherapeuticClass
- Anti-coagulants
- Oral Anti-coagulants
StorageConditions
- Do not store above 30°C
- Keep away from light and out of the reach of children