Unifarin 2.5 mg (Tablet)

Indications

• Prophylaxis and/or treatment of thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement
• Indicated to reduce the risk of death, recurrent myocardial infarction, and thromboembolic events such as stroke or systemic embolization after myocardial infarction
• Prophylaxis and treatment of venous thrombosis and pulmonary embolism
• Transient ischaemic attacks

Description

• Anticoagulant that inhibits the synthesis of vitamin K dependent clotting factors
• Acts on clotting factors II, VII, IX and X
• Anticoagulant effect occurs within 24 hours after administration

Pharmacology

• Acts as a vitamin K antagonist
• Inhibits the production of vitamin K by vitamin K epoxide reductase
• Affects coagulation factors VII, IX, X, and thrombin

Dosage & Administration

• Usual adult induction dose is 10 mg daily for 2 days
• Subsequent maintenance dose depends upon prothrombin time
• Maintenance dose for adults is usually 3 to 9 mg daily

Interaction

• Has greater potential for clinically significant drug interactions
• Patients should be warned against taking or withdrawing any drug without physician advice

Contraindications

• Cannot be administered in cases of actual or potential hemorrhagic conditions
• Severe hepatic or renal disease
• Pregnancy
• Known hypersensitivity to warfarin
• Bacterial endocarditis

Side Effects

• Principal adverse effect is hemorrhage
• Other adverse reactions include nausea, vomiting, and diarrhea

Pregnancy & Lactation

• Contraindicated in the first trimester of pregnancy
• Passes through the placental barrier and may cause fatal hemorrhage to the fetus
• Appears in the milk of nursing mothers in an inactive form

Precautions & Warnings

• Periodic determination of prothrombin time (PT)/international normalized ratio (INR) is essential
• Numerous factors may influence patient's response to anticoagulants

Overdose Effects

• Excessive depression of the coagulation activity can be corrected by temporary withdrawal of warfarin
• Vitamin K may be required to supplement specific treatment with co-factor concentrates

Therapeutic Class

• Anti-coagulants
• Oral Anti-coagulants

Storage Conditions

• Do not store above 30°C
• Keep away from light and out of the reach of children

Related Brands

• Farin 2 mg (Tablet) - concord-pharmaceuticals-ltd
• Farin 1 mg (Tablet) - concord-pharmaceuticals-ltd
• Unifarin 5 mg (Tablet) - unimed-unihealth-pharmaceuticals-ltd