Unifarin 5 mg (Tablet)
Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Warfarin sodium |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Prophylaxis and/or treatment of thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement
- Indicated to reduce the risk of death, recurrent myocardial infarction, and thromboembolic events such as stroke or systemic embolization after myocardial infarction
- Prophylaxis and treatment of venous thrombosis and pulmonary embolism
- Transient ischaemic attacks
Description
Anticoagulant that acts by inhibiting the synthesis of vitamin K dependent clotting factors (Factors II, VII, IX, and X).
Pharmacology
- Antagonist of vitamin K
- Inhibits the production of vitamin K by vitamin K epoxide reductase
- Interrupts the coagulation cascade
- Creates a hypercoagulable state for a short time
Dosage & Administration
- Usual adult induction dose of warfarin is 10 mg daily for 2 days
- Subsequent maintenance dose depends upon the prothrombin time (INR)
- Maintenance dose is usually 3 to 9 mg daily
- Initial dose for children is usually 0.1 mg.kg^-1.d^-1
Interaction
Has a greater potential for clinically significant drug interactions
Contraindications
- Actual or potential hemorrhagic conditions
- Severe hepatic or renal disease
- Pregnancy
- Known hypersensitivity to warfarin
- Bacterial endocarditis
Side Effects
- Hemorrhage
- Nausea
- Vomiting
- Diarrhea
- Hypersensitivity
- Rash
- Alopecia
- Unexplained drop in haematocrit
- Skin necrosis
- Jaundice
- Hepatic dysfunction
Pregnancy & Lactation
- Contraindicated in the first trimester of pregnancy
- Passes through the placental barrier
- Can cause fatal hemorrhage to the fetus
- Appears in the milk of nursing mothers
Precautions & Warnings
- Periodic determination of prothrombin time (PT)/international normalized ratio (INR) is essential
- Numerous factors may influence response to anticoagulants
- Monitor patient's response with additional PT/INR determination after discharge from the hospital, and whenever other medications are initiated, discontinued or taken irregularly
Overdose Effects
Excessive depression of the coagulation activity can be corrected by temporary withdrawal of warfarin accompanied by infusion of fresh-frozen plasma or whole blood
Therapeutic Class
Anti-coagulants, Oral Anti-coagulants
Storage Conditions
Do not store above 30°C. Keep away from light and out of the reach of children