Koreg 6.25 mg (Tablet)
Unit Price: ৳ 3.01 (3 x 10: ৳ 90.30)
Strip Price: ৳ 30.10
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | Silva pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of mild, moderate or severe heart failure
- Treatment of ischemic or cardiomyopathic origin heart failure
- Reduction of disease progression
- Conjunction with digitalis, diuretics and ACE inhibitor
- Use in patients unable to tolerate an ACE inhibitor
Pharmacology
- Non-selective antagonism of β-adrenergic receptors
- α-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
- Used in the treatment of hypertension
- Used in the treatment of angina pectoris
- Used in the treatment of congestive heart failure
Dosage & Administration
- Initial dose of 12.5 mg once daily for hypertension
- Increased dose to the usual dose of 25 mg once daily for hypertension
- Initial dose of 12.5 mg twice daily for angina pectoris
- Recommended dosage of 25 mg twice daily for angina pectoris
- Initial dose of 3.125 mg twice daily for heart failure
- Increased dose at intervals of at least 2 weeks for heart failure
Interaction
- Increased levels of digoxin when taken together with Koreg
- Recommendation for increased monitoring of digoxin
- 60% decrease in Cmax and AUC with rifampin pretreatment
- Did not alter the in vitro plasma protein binding of warfarin
- β-receptor antagonists potentiate the pressor reaction with clonidine
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma or related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome without a permanent pacemaker in place
- Cardiogenic shock
- Severe bradycardia
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastro-intestinal disturbances
- Bradycardia
- Peripheral oedema
- Dry mouth
- Impotence
- Disturbances of micturition
- Heart failure
- Changes in liver enzymes
- Thrombocytopenia
- Leukopenia
Pregnancy & Lactation
- Not to be used during breast-feeding
- No studies on safety and efficacy in children
- Not to be used during pregnancy
- Animal studies have shown crossing of the placental barrier
- No information on safety and efficacy in neonates
Precautions & Warnings
- Caution in hepatic impairment
- Monitor clinical status for 2-3 hours after initiation and dose increase
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C temperature
- Keep away from light & moisture
- Keep out of the reach of children