Koreg 12.5 mg (Tablet)
Unit Price: ৳ 5.02 (3 x 10: ৳ 150.60)
Strip Price: ৳ 50.20
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | Silva pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of mild heart failure
- Treatment of moderate heart failure
- Treatment of severe heart failure
- Treatment of ischemic heart failure
- Treatment of cardiomyopathic heart failure
- Reduction of disease progression
- Cardiovascular death prevention
- Cardiovascular hospitalization prevention
- Medication adjustment
- Patients intolerance to ACE inhibitor
- Patients not receiving digitalis therapy
- Patients not receiving hydralazine therapy
- Patients not receiving nitrate therapy
Pharmacology
- Non-selective antagonism of β-adrenergic receptors
- a-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
- Treatment of hypertension
- Treatment of angina pectoris
- Treatment of congestive heart failure
Dosage & Administration
- Initial dosage in hypertension - 12.5 mg once daily
- Usual dosage in hypertension - 25 mg once daily
- Maximum dosage in hypertension - 50 mg daily
- Initial dosage in angina pectoris - 12.5 mg twice daily
- Recommended dosage in angina pectoris - 25 mg twice daily
- Maximum dosage in angina pectoris - 50 mg daily
- Initial dosage in heart failure - 3.125 mg twice daily
- Maximum dosage in heart failure - 25 mg twice daily (in patients less than 85 kg body-weight) to 50 mg twice daily (in patients over 85 kg)
Interaction
- Interaction with Digoxin
- Interaction with Rifampin
- Interaction with Warfarin
- Interaction with Clonidine
- Increased monitoring of digoxin recommended
- 60% decrease in Cmax and AUC with Rifampin pretreatment
- No alteration of in vitro plasma protein binding of warfarin with Koreg
- Potentiation of pressor reaction with clonidine withdrawal
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma
- Related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome
- Cardiogenic shock
- Severe bradycardia
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastro-intestinal disturbances
- Bradycardia
- Diminished peripheral circulation
- Peripheral oedema
- Painful extremities
- Dry mouth
- Dry eyes
- Eye irritation
- Disturbed vision
- Impotence
- Disturbances of micturition
- Influenza-like symptoms
- Angina
- AV block
- Exacerbation of intermittent claudication
- Exacerbation of Raynaud's phenomenon
- Allergic skin reactions
- Exacerbation of psoriasis
- Nasal stuffiness
- Wheezing
- Depressed mood
- Sleep disturbances
- Paresthesia
- Changes in liver enzymes
- Thrombocytopenia
- Leukopenia
Pregnancy & Lactation
- Not to be used during breast-feeding
- No studies performed in lactating women
- Excretion in breast milk shown in animal studies
- Safety and efficacy not established in children
- Not to be used during pregnancy
- Crosses the placental barrier
Precautions & Warnings
- Caution in hepatic impairment
- Clinical status monitoring after initiation
- Heart failure monitoring after increasing each dose
- Renal function monitoring before increasing dose
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children