Ale DS 400 mg (Chewable Tablet)

Unit Price: ৳ 4.00

Medicine Details

Category Details
Generic Albendazole
Company Aztec pharmaceuticals ltd

Indications

  • Single and mixed infestations of hookworm, roundworm, threadworm, whipworm, strongyloides, tapeworm, opisthorchi, hydatid

Description

  • Benzimidazole anthelmintic
  • Active against most nematodes and some cestodes
  • Used in the treatment of intestinal nematode infections
  • Used in higher doses in the treatment of hydatid disease
  • Vermicidal, ovicidal, and larvicidal activity
  • Inhibitory effect on tubulin polymerization

Pharmacology

  • Broad spectrum anthelmintic
  • Exhibits vermicidal, ovicidal, and larvicidal activities
  • Blocks glucose uptake in susceptible helminths
  • Depletes energy level until inadequate for survival
  • Extensively metabolized, probably in the liver
  • Poorly absorbed from the gastrointestinal tract

Dosage & Administration

  • Adults & children over 2 years: 400 mg as a single dose for various infections
  • Children of 1-2 years: Recommended dose of 200 mg
  • Children under 1 year: Not recommended
  • In hydatid disease: Doses for different patient weights and different types of echinococcosis
  • In giardiasis: 400 mg once daily for five days

Interaction

  • No reported pharmacodynamic or pharmacokinetic interactions

Contraindications

  • Not normally used in neonates
  • Possible reduction of dose for children weighing less than 10 kg
  • Should not be given during pregnancy or to women thought to be pregnant
  • No evidence to suggest altering the dose in renal, hepatic, or cardiac failure

Side Effects

  • Gastrointestinal disturbances
  • Headache
  • Dizziness
  • Changes in liver enzymes
  • Rarely reversible alopecia
  • Rash
  • Fever
  • Blood disorders including leucopenia and pancytopenia
  • Allergic shock if cyst leakage
  • Convulsion and meningism in cerebral disease

Pregnancy & Lactation

  • US FDA Pregnancy category C
  • Should be avoided in pregnancy and lactation unless benefits outweigh risks

Precautions & Warnings

  • Blood counts and liver function tests before treatment and during each cycle
  • Breastfeeding caution
  • Exclude pregnancy before starting treatment
  • Constant medical supervision in echinococcosis treatment

Therapeutic Class

  • Anthelmintic

Storage Conditions

  • Keep in a dry place
  • Away from light and heat
  • Keep out of the reach of children

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