Ale DS 400 mg (Chewable Tablet)
Unit Price: ৳ 4.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Albendazole |
| Company | Aztec pharmaceuticals ltd |
Indications
- Single and mixed infestations of hookworm, roundworm, threadworm, whipworm, strongyloides, tapeworm, opisthorchi, hydatid
Description
- Benzimidazole anthelmintic
- Active against most nematodes and some cestodes
- Used in the treatment of intestinal nematode infections
- Used in higher doses in the treatment of hydatid disease
- Vermicidal, ovicidal, and larvicidal activity
- Inhibitory effect on tubulin polymerization
Pharmacology
- Broad spectrum anthelmintic
- Exhibits vermicidal, ovicidal, and larvicidal activities
- Blocks glucose uptake in susceptible helminths
- Depletes energy level until inadequate for survival
- Extensively metabolized, probably in the liver
- Poorly absorbed from the gastrointestinal tract
Dosage & Administration
- Adults & children over 2 years: 400 mg as a single dose for various infections
- Children of 1-2 years: Recommended dose of 200 mg
- Children under 1 year: Not recommended
- In hydatid disease: Doses for different patient weights and different types of echinococcosis
- In giardiasis: 400 mg once daily for five days
Interaction
- No reported pharmacodynamic or pharmacokinetic interactions
Contraindications
- Not normally used in neonates
- Possible reduction of dose for children weighing less than 10 kg
- Should not be given during pregnancy or to women thought to be pregnant
- No evidence to suggest altering the dose in renal, hepatic, or cardiac failure
Side Effects
- Gastrointestinal disturbances
- Headache
- Dizziness
- Changes in liver enzymes
- Rarely reversible alopecia
- Rash
- Fever
- Blood disorders including leucopenia and pancytopenia
- Allergic shock if cyst leakage
- Convulsion and meningism in cerebral disease
Pregnancy & Lactation
- US FDA Pregnancy category C
- Should be avoided in pregnancy and lactation unless benefits outweigh risks
Precautions & Warnings
- Blood counts and liver function tests before treatment and during each cycle
- Breastfeeding caution
- Exclude pregnancy before starting treatment
- Constant medical supervision in echinococcosis treatment
Therapeutic Class
- Anthelmintic
Storage Conditions
- Keep in a dry place
- Away from light and heat
- Keep out of the reach of children