Vermin-DS 400 mg (Chewable Tablet)
Unit Price: ৳ 4.50 (25's pack: ৳ 112.50)
Medicine Details
| Category | Details |
|---|---|
| Generic | Albendazole |
| Company | Nipa pharmaceuticals ltd |
Indications
- Hookworm infestation
- Roundworm infestation
- Threadworm infestation
- Whipworm infestation
- Strongyloides infestation
- Tapeworm infestation
- Opisthorchi infestation
- Hydatid infestation
Description
- Benzimidazole anthelmintic
- Active against most nematodes and some cestodes
- Exhibits vermicidal, ovicidal, and larvicidal activity
- Inhibitory effect on tubulin polymerization
- Loss of cytoplasmic microtubules
Pharmacology
- Broad spectrum anthelmintic
- Blocks glucose uptake in susceptible helminths
- Depletes energy level of helminths
- Immobilization and subsequent parasite death
- Binding and inhibition of parasite tubulin polymerization
- Extensively metabolized, probably in the liver
- Poorly absorbed from the gastrointestinal tract
- Anthelmintic activity of metabolites
- Excretion of metabolites in urine
Dosage & Administration
- Adult dosage of 400 mg as a single dose
- Children over 2 years dose of 400 mg as a single dose
- Recommended dose for children of 1-2 years
- Dosing in Hydatid disease based on patient weight
- Treatment duration for different infestations
- Dosage for giardiasis
Interaction
- No reported pharmacodynamic interaction
- No reported pharmacokinetic interaction
Contraindications
- Not for use in neonates
- Consider reduced dose in children weighing less than 10 kg
- Avoid use in pregnant women
- No need for dose alteration in renal, hepatic, or cardiac failure
Side Effects
- Gastrointestinal disturbances
- Headache
- Dizziness
- Changes in liver enzymes
- Rarely reversible alopecia
- Rash
- Fever
- Blood disorders including leucopenia and pancytopenia
- Allergic shock if cyst leakage
- Convulsion and meningism in cerebral disease
Pregnancy & Lactation
- US FDA Pregnancy category C
- Should be avoided in pregnancy and lactation unless benefits outweigh risks
Precautions & Warnings
- Blood counts and liver function tests before and during treatment
- Caution during breastfeeding
- Exclude pregnancy before treatment
- Medical supervision in Echinococcosis treatment
Therapeutic Class
- Anthelmintic
Storage Conditions
- Keep in a dry place
- Away from light and heat
- Keep out of the reach of children