Ucardol 12.5 mg (Tablet)
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of mild, moderate or severe heart failure
- Reduction of disease progression
- Usage in patients unable to tolerate ACE inhibitor
- Usage in patients not receiving digitalis, hydralazine or nitrate therapy
Pharmacology
- Non-selective antagonism of β-adrenergic receptors
- A-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
- Treatment of hypertension, angina pectoris, and congestive heart failure
Dosage & Administration
- Initial dosage in hypertension: 12.5 mg once daily, increased to 25 mg once daily
- Initial dosage in angina pectoris: 12.5 mg twice daily for the first 2 days, then 25 mg twice daily
- Initial dosage in heart failure: 3.125 mg twice daily, with subsequent increments at intervals of at least 2 weeks
Interaction
- Increased levels of digoxin when taken together
- Significant decrease in Cmax and AUC with rifampin pretreatment
- No alteration in in vitro plasma protein binding of warfarin
- Potentiation of the pressor reaction when used with clonidine
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma or related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome without a permanent pacemaker
- Cardiogenic shock or severe bradycardia
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastro-intestinal disturbances
- Bradycardia
- Diminished peripheral circulation
- Peripheral oedema
- Dry mouth
- Impotence
- Influenza-like symptoms
- Angina
- Exacerbation of intermittent claudication or Raynaud's phenomenon
Pregnancy & Lactation
- Not to be used during breast-feeding
- No studies in lactating women
- Animal studies showing excretion in breast milk
- Safety and efficacy not established in children
- Not to be used during pregnancy
- Animal studies showing crossing of placental barrier
- No information on safety and efficacy in neonates
Precautions & Warnings
- Caution in hepatic impairment
- Monitor clinical status after initiation and increasing each dose
- Ensure renal function and heart failure are not deteriorating before increasing dose
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children