TCL-R 40 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Atorvastatin calcium |
| Company | Aristopharma ltd |
| Also available as |
Title
TCL-R 40 mg Tablet
Categories
- Medicine
- Statins
- Cholesterol Lowering Drugs
Description
TCL-R 40 mg Tablet is a selective inhibitor of HMG-CoA reductase used to reduce elevated total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B), and triglycerides levels in various diseases when response to diet and other non-pharmacological measures is inadequate.
Primary indication
Reduction of total cholesterol and LDL cholesterol
Dosage form
Tablet
Dosage strength
40 mg
Dosage instructions
- Take by mouth once daily
- Can be taken with or without food
Absorption
Rapidly absorbed after oral administration
Distribution
Mean volume of distribution is approximately 381 liters
Metabolism
Extensively metabolized to ortho- and parahydroxylated derivatives
Excretion
Eliminated primarily in bile
Precautions warnings
Liver function tests should be performed before the initiation of treatment and periodically thereafter
Storage conditions
Keep in a dry place away from light and heat. Keep out of the reach of children
Chemical structure
- Molecular Formula: C33H35FN2O5
- Chemical Structure Image: https://medex.com.bd/storage/res/g-res-92-atorvastatin-calcium-chemical-structure-vKDE8RIA4syu8MLTgdLW.svg
Commonly asked questions
- What is TCL-R 40 mg Tablet?
- How should I take TCL-R 40 mg Tablet?
- What are the uses of TCL-R 40 mg Tablet?
- What are the Side Effects of TCL-R 40 mg Tablet?
- What are the instructions for storage and disposal TCL-R 40 mg Tablet?
- Is TCL-R 40 mg Tablet used for lowering cholesterol?
- Will taking TCL-R 40 mg Tablet increase my risk of diabetes?
- For how long do I need to take TCL-R 40 mg Tablet? Is it safe for long-term use?
- Does TCL-R 40 mg Tablet cause weight loss?
- Can I stop taking TCL-R 40 mg Tablet?
- Does TCL-R 40 mg Tablet cause memory loss?
- Does TCL-R 40 mg Tablet make you tired?
- Can TCL-R 40 mg Tablet be prescribed to children?
- Is TCL-R 40 mg Tablet a blood thinner?
- Quick Tips
Interaction
- Antacid: Plasma concentrations of atorvastatin decreased approximately 35%
- Colestipol: Plasma concentrations of atorvastatin decreased approximately 25%
- Digoxin: Steady-state plasma digoxin concentrations increased by approximately 20%
- Erythromycin: Plasma concentrations of atorvastatin increased approximately 40%
- Oral Contraceptives: AUC values for norethindrone and ethinyl estradiol increased by approximately 30% and 20%
- Warfarin: TCL-R had no clinically significant effect on prothrombin time
Pregnancy Lactation
- Pregnancy: Atorvastatin is contraindicated during pregnancy. Safety in pregnant women has not been established
- Lactation: Not known whether atorvastatin or its metabolites are excreted in human milk
Side effects
- Constipation
- Flatulence
- Dyspepsia
- Abdominal pain
- Infection
- Headache
- Back pain
- Rash
- Asthenia
- Arthralgia
- Myalgia
Contraindications
- Hypersensitivity to any component of this medication
- Active liver disease or unexplained persistent elevations of serum transaminases
- History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors
Overdose effects
Specific treatment is not available for atorvastatin overdose
Therapeutic Class
Other Anti-anginal & Anti-ischaemic drugs, Statins
Use in Special Populations
- Geriatric: Plasma concentrations of TCL-R are higher in healthy elderly subjects
- Pediatric: Pharmacokinetic data in the pediatric population are not available
- Gender: No clinically significant difference in LDL-C reduction with TCL-R between men and women
- Renal Insufficiency: No influence on the plasma concentrations or LDL-C reduction of TCL-R in patients with renal dysfunction
- Hemodialysis: Not expected to significantly enhance clearance of TCL-R
- Hepatic Insufficiency: Plasma concentrations of TCL-R are markedly increased in patients with chronic alcoholic liver disease