Optivas 20 mg (Tablet)

Unit Price: ৳ 18.05 (2 x 10: ৳ 361.00)
Strip Price: ৳ 180.50

Medicine Details

Category Details
Generic Atorvastatin calcium
Company Concord pharmaceuticals ltd
Also available as
Optivas 10 mg tablet

Title

  • Optivas 20 mg Tablet

Categories

  • Medicine
  • Pharmaceutical

Description

  • A selective inhibitor of HMG-CoA reductase for reducing cholesterol levels and preventing heart attacks
  • Treatment for conditions like Mixed Dyslipidemia and Hypertriglyceridemia

Indications

  • Reduction of total cholesterol and LDL cholesterol in familial hypercholesterolaemia
  • Treatment of mixed dyslipidemia and hypertriglyceridaemia
  • Reduction of cardiac ischaemic events in patients with coronary artery disease
  • Reduction of cholesterol concentrations associated with diabetes mellitus or renal transplantation

Pharmacology

  • Selective inhibitor of HMG-CoA reductase
  • Lowers plasma cholesterol and lipoprotein levels
  • Increases hepatic LDL receptors for enhanced uptake and catabolism of LDL

Absorption

  • Rapidly absorbed after oral administration
  • Maximum plasma concentrations occur within 1 to 2 hours
  • Extent of absorption increases with dose

Distribution

  • Mean volume of distribution of approximately 381 liters
  • 98% bound to plasma proteins
  • Unlikely to be secreted in human milk

Metabolism

  • Extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products
  • Importance of metabolism by cytochrome P450 3A4

Excretion

  • Eliminated primarily in bile following hepatic and/or extra-hepatic metabolism
  • Mean plasma elimination half-life in humans is approximately 14 hours

Dosage & Administration

  • Adults: Usually 10 mg once daily; may be increased to max. 80 mg once daily if necessary
  • Recommended starting dose is 10 or 20 mg once daily
  • Dosage range: 10 to 80 mg once daily

Interaction

  • Risk of myopathy increased with concurrent administration of certain drugs
  • Effect on plasma concentrations when coadministered with antacid, colestipol, digoxin, erythromycin, oral contraceptives, and warfarin

Contraindications

  • Hypersensitivity to any component
  • Active liver disease or unexplained persistent elevations of serum transaminases
  • History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors

Side Effects

  • Constipation
  • Flatulence
  • Dyspepsia
  • Abdominal pain
  • Infection
  • Headache
  • Back pain
  • Rash
  • Asthenia
  • Arthralgia
  • Myalgia

Pregnancy & Lactation

  • Contraindicated during pregnancy
  • Safety not established in pregnant women
  • Not known whether excreted in human milk
  • Atorvastatin reduces fetal levels of mevalonate, a precursor of cholesterol biosynthesis

Precautions & Warnings

  • Liver function tests should be performed before initiation of treatment
  • Use with caution in patients who consume substantial quantities of alcohol or have a history of liver disease

Use in Special Populations

  • Plasma concentrations are higher in healthy elderly subjects
  • No clinically significant difference in LDL-C reduction between men and women
  • Renal disease has no influence on plasma concentrations or LDL-C reduction
  • Hemodialysis not expected to significantly enhance clearance

Overdose Effects

  • Specific treatment not available
  • Symptomatic treatment and supportive measures instituted
  • Liver function tests and serum CK levels should be monitored

Therapeutic Class

  • Other Anti-anginal & Anti-ischaemic drugs
  • Statins

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C33H35FN2O5
  • Chemical Structure Image URL: https://medex.com.bd/storage/res/g-res-92-atorvastatin-calcium-chemical-structure-vKDE8RIA4syu8MLTgdLW.svg

Commonly Asked Questions

  • What is Optivas 20 mg Tablet?
  • How should I take Optivas 20 mg Tablet?
  • What are the uses of Optivas 20 mg Tablet?
  • What are the Side Effects of Optivas 20 mg Tablet?
  • What are the instructions for storage and disposal of Optivas 20 mg Tablet?
  • Is Optivas 20 mg Tablet used for lowering cholesterol?
  • Will taking Optivas 20 mg Tablet increase my risk of diabetes?
  • For how long do I need to take Optivas 20 mg Tablet? Is it safe for long-term use?
  • Does Optivas 20 mg Tablet cause weight loss?
  • Can I stop taking Optivas 20 mg Tablet?
  • Does Optivas 20 mg Tablet cause memory loss?
  • Does Optivas 20 mg Tablet make you tired?
  • Can Optivas 20 mg Tablet be prescribed to children?
  • Is Optivas 20 mg Tablet a blood thinner?
  • Quick Tips: Safe usage, monitoring of liver function, and precautions for diabetics

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