Aster 10 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Atorvastatin calcium
Company Euro pharma ltd
Also available as
Aster 20 mg tablet

Title

  • Aster 10 mg Tablet

Categories

  • Medicine
  • Pharmaceutical

Description

  • Cholesterol-lowering drug
  • HMG-CoA reductase inhibitor

Dosage form

  • Tablet

Dosage strength

10 mg

Therapeutic class

  • Statins
  • Anti-anginal drug
  • Anti-ischaemic drug

Indications

  • Reduction of total cholesterol and LDL cholesterol in familial hypercholesterolaemia
  • Reduction of cholesterol and triglycerides in mixed dyslipidemia
  • Treatment of hypertriglyceridaemia
  • Treatment of dysbetalipoproteinaemia
  • Reduction of cardiac ischaemic events in coronary artery disease
  • Reduction of cholesterol levels associated with diabetes mellitus or renal transplantation

Pharmacology

  • Selective inhibitor of HMG-CoA reductase
  • Lowers plasma cholesterol and lipoprotein levels
  • Increases hepatic LDL receptors for enhanced uptake and catabolism of LDL

Absorption

Rapidly absorbed after oral administration; maximum plasma concentrations occur within 1 to 2 hours

Distribution

  • Mean volume: Approximately 381 liters
  • Plasma protein binding: 98%

Metabolism

  • Extensively metabolized to ortho- and parahydroxylated derivatives
  • Metabolized by cytochrome P450 3A4
  • 70% of circulating inhibitory activity attributed to active metabolites

Excretion

  • Primarily in bile following hepatic and/or extra-hepatic metabolism
  • Mean plasma elimination half-life approximately 14 hours

Interaction

  • Increased risk of myopathy with concurrent administration of certain drugs
  • Changes in plasma concentrations when coadministered with antacid, colestipol, digoxin, erythromycin, oral contraceptives, and warfarin

Contraindications

  • Hypersensitivity to any component of the medication
  • Active liver disease or unexplained persistent elevations of serum transaminases

Side effects

  • Constipation
  • Flatulence
  • Dyspepsia
  • Abdominal pain
  • Infection
  • Headache
  • Back pain
  • Rash
  • Asthenia
  • Arthralgia
  • Myalgia

Pregnancy and lactation

  • Contraindicated during pregnancy
  • Not recommended during breastfeeding

Precautions and warnings

Liver function tests should be performed before the initiation of treatment and periodically thereafter

Special populations

  • Geriatric: Plasma concentrations are higher in healthy elderly subjects
  • Pediatric: Pharmacokinetic data not available
  • Gender: No clinically significant difference in LDL-C reduction between men and women
  • Renal insufficiency: No influence on plasma concentrations or LDL-C reduction
  • Hemodialysis: Not expected to significantly enhance clearance
  • Hepatic insufficiency: Markedly increased plasma concentrations in chronic alcoholic liver disease

Overdose effects

Specific treatment not available; symptomatically managed with supportive measures

Storage conditions

Keep in a dry place away from light and heat

Chemical structure

  • Molecular formula: C33H35FN2O5
  • Chemical structure image: https://medex.com.bd/storage/res/g-res-92-atorvastatin-calcium-chemical-structure-vKDE8RIA4syu8MLTgdLW.svg

Common questions

  • What is the drug used for?
  • How should the drug be taken?
  • What are the uses of the drug?
  • What are the common side effects of the drug?
  • Instruction for storage and disposal of the drug
  • Is the drug used for lowering cholesterol?
  • Will taking the drug increase the risk of diabetes?
  • For how long should the drug be taken? Is it safe for long-term use?
  • Does the drug cause weight loss?
  • Can the drug be stopped?
  • Does the drug cause memory loss?
  • Does the drug make you tired?
  • Can the drug be prescribed to children?
  • Is the drug a blood thinner?
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