Lipiva 20 mg (Tablet)

Unit Price: ৳ 18.00 (30's pack: ৳ 540.00)

Medicine Details

Category Details
Generic Atorvastatin calcium
Company Leon pharmaceuticals ltd
Also available as
Lipiva 10 mg tablet

Title

  • Lipiva 20 mg Tablet

Categories

  • Cholesterol-lowering medication
  • Statins
  • HMG-CoA reductase inhibitor

Indications

  • Reducing total cholesterol levels
  • Lowering LDL cholesterol levels
  • Decreasing triglycerides levels
  • Treating familial hypercholesterolaemia
  • Managing mixed dyslipidemia
  • Addressing hypertriglyceridaemia
  • Dealing with dysbetalipoproteinaemia
  • Preventing cardiac ischaemic events
  • Managing hypercholesterolemia associated with diabetes or renal transplantation

Pharmacology

  • Selective inhibitor of HMG-CoA reductase
  • Lowers plasma cholesterol and lipoprotein levels
  • Inhibits cholesterol synthesis in the liver
  • Increases hepatic LDL receptors for enhanced uptake and catabolism of LDL

Absorption

  • Rapidly absorbed after oral administration
  • Maximum plasma concentrations within 1 to 2 hours
  • Extent of absorption increases with dose

Distribution

  • Mean volume of distribution approximately 381 liters
  • 98% bound to plasma proteins
  • Likely to be secreted in human milk

Metabolism

  • Extensively metabolized to ortho- and parahydroxylated derivatives
  • Metabolism primarily by cytochrome P450 3A4
  • Significant in vitro inhibition by metabolites
  • Ortho-hydroxy metabolite undergoes further glucuronidation

Excretion

  • Eliminated primarily in bile following hepatic and/or extra-hepatic metabolism
  • Mean plasma elimination half-life approximately 14 hours
  • Contribution of active metabolites extends half-life of inhibitory activity to 20 to 30 hours

Dosage & Administration

  • Adults usually start with 10 mg once daily
  • Dose may be increased at intervals of at least 4 weeks to max. 80 mg once daily
  • Pediatric dose starts from 10 mg once daily
  • Dose adjustment based on lipid levels within 2 to 4 weeks of initiation

Interaction

  • Increased risk of myopathy with concurrent administration of certain drugs
  • Plasma concentrations affected by coadministration with antacid, colestipol, digoxin, erythromycin, oral contraceptives, and warfarin

Contraindications

  • Hypersensitivity to any component of the medication
  • Active liver disease or unexplained persistent elevations of serum transaminases
  • History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors

Side Effects

  • Constipation
  • Flatulence
  • Dyspepsia
  • Abdominal pain
  • Infection
  • Headache
  • Back pain
  • Rash
  • Asthenia
  • Arthralgia
  • Myalgia

Pregnancy & Lactation

  • Atorvastatin is contraindicated during pregnancy
  • Safety in pregnant women not established
  • Excretion in human milk not known
  • Potential for serious adverse reactions during breastfeeding

Precautions & Warnings

  • Liver function tests before initiation of treatment
  • Caution in patients with substantial alcohol consumption or history of liver disease
  • Discontinuation if markedly elevated CPK levels or myopathy occur

Use in Special Populations

  • Higher plasma concentrations in elderly subjects
  • No influence on plasma concentrations or LDL-C reduction in renal insufficiency
  • Markedly increased plasma concentrations in chronic alcoholic liver disease

Overdose Effects

  • No specific treatment available for atorvastatin overdose
  • Symptomatic treatment and supportive measures required
  • Liver function tests and serum CK levels monitoring recommended

Therapeutic Class

  • Other Anti-anginal & Anti-ischaemic drugs
  • Statins

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C33H35FN2O5

Common Questions

  • What is Lipiva 20 mg Tablet?
  • How should I take Lipiva 20 mg Tablet?
  • What are the uses of Lipiva 20 mg Tablet?
  • What are the Side Effects of Lipiva 20 mg Tablet?
  • What are the instructions for storage and disposal of Lipiva 20 mg Tablet?
  • Is Lipiva 20 mg Tablet used for lowering cholesterol?
  • Will taking Lipiva 20 mg Tablet increase my risk of diabetes?
  • For how long do I need to take Lipiva 20 mg Tablet? Is it safe for long-term use?
  • Does Lipiva 20 mg Tablet cause weight loss?
  • Can I stop taking Lipiva 20 mg Tablet?
  • Does Lipiva 20 mg Tablet cause memory loss?
  • Does Lipiva 20 mg Tablet make you tired?
  • Can Lipiva 20 mg Tablet be prescribed to children?
  • Is Lipiva 20 mg Tablet a blood thinner?
  • Quick Tips

Additional Information

  • Cholesterol-lowering medication with diverse applications
  • Selective inhibitor with well-documented pharmacological profile
  • Diverse dosage options for effective management
  • Important precautions for special patient populations
  • Chemical structure and storage information provided

Related Brands