Labecard 50 mg/10 ml (IV Injection or Infusion)

Indications

• Hypertension
• Hypertension in pregnancy
• Hypertension after stroke
• Hypertension with angina
• Hypertension following acute myocardial infarction
• Hypertensive crisis
• Anaesthesia when a hypotensive technique is indicated

Pharmacology

• Adrenergic receptor-blocking agent
• Selective alpha 1-adrenergic and nonselective beta-adrenergic receptor-blocking actions
• Decrease in blood pressure
• Peak plasma levels occurring 1 to 2 hours after oral administration
• Plasma half-life of about 6 to 8 hours
• Approximately 55% to 60% of a dose appears in the urine within the first 24 hours

Dosage & Administration

• Recommended initial dosage of 100 mg twice daily for adults
• Usual maintenance dosage between 200 and 400 mg twice daily
• Patients with severe hypertension may require from 1,200 to 2,400 mg per day
• Elderly patients usually require between 100 and 200 mg twice daily
• Intravenous injection and infusion dosages for various conditions
• Different dosage for hypertensive pregnancy, acute myocardial infarction, stroke, and other causes
• Recommended starting dose for hypotensive anaesthesia

Interaction

• Enhancement of hypotensive effects with halothane
• Potential interactions with Class I antiarrhythmic agents, calcium antagonists, prostaglandin synthetase inhibitors, tricyclic antidepressants, and cimetidine

Contraindications

• Hypersensitivity to the medicine
• Second or third degree heart block
• Infranodal A-V block
• Uncontrolled heart failure
• Sick-sinus syndrome
• Cardiogenic shock
• Severe and prolonged hypotension or severe bradycardia
• Bronchial asthma or obstructive lung disorders

Side Effects

• Postural hypotension
• Tiredness
• Weakness
• Headache
• Rashes
• Scalp tingling
• Difficulty in micturition
• Epigastric pain
• Nausea
• Vomiting
• Liver damage

Pregnancy & Lactation

• Teratogenic studies in rats and rabbits
• No reproducible evidence of fetal malformations
• Small amounts excreted in human milk
• Caution during nursing

Precautions & Warnings

• Rare reports of severe hepatocellular injury
• Reversible hepatic injury
• Caution in patients with hepatic impairment
• Use with caution in patients with peripheral vascular disease

Overdose Effects

• Excessive hypotension
• Excessive bradycardia
• Gastric lavage or pharmacologically induced emesis for removal of the drug
• Administration of atropine, digitalis glycoside, diuretic, vasopressors, epinephrine in case of overdose effects

Therapeutic Class

• Alpha adrenoceptor blocking drugs
• Beta-adrenoceptor blocking drugs

Storage Conditions

• Store in a cool & dry place protected from light
• Keep out of reach of children

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