Liptor 40 mg (Tablet)

Unit Price: ৳ 27.00 (1 x 10: ৳ 270.00)
Strip Price: ৳ 270.00

Medicine Details

Category Details
Generic Atorvastatin calcium
Company Acme laboratories ltd
Also available as
Liptor 10 mg tablet Liptor 20 mg tablet

Title

Liptor 40 mg Tablet

Categories

  • Medicine
  • Pharmacology
  • Cholesterol-lowering

Description

Liptor 40 mg Tablet is a selective inhibitor of HMG-CoA reductase. It is used to reduce total cholesterol, LDL cholesterol, and triglyceride levels. It is also indicated for the prevention of cardiovascular events and has contraindications in certain populations.

DosageAndAdministration

Usually 10 mg once daily for adults, may be increased to max. 80 mg once daily if necessary. For children (10-18 years), the initial dose is 10 mg once daily, increased if necessary to a usual max. of 20 mg once daily.

Pharmacology

  • ModeOfAction: Selective inhibitor of HMG-CoA reductase responsible for lowering plasma cholesterol and lipoprotein levels.
  • Absorption: Rapidly absorbed with maximum plasma concentrations occurring within 1 to 2 hours.
  • Distribution: Mean volume of distribution is approximately 381 liters, with 98% bound to plasma proteins.
  • Metabolism: Extensively metabolized to active metabolites, mainly by cytochrome P450 3A4.
  • Excretion: Primarily eliminated in bile following hepatic and/or extra-hepatic metabolism.

Interactions

  • Antacid: Plasma concentrations of atorvastatin decreased approximately 35% when coadministered with antacid suspension, but LDL-C reduction was not altered.
  • Colestipol: Plasma concentrations of atorvastatin decreased approximately 25% when coadministered with colestipol, but LDL-C reduction was greater.
  • Digoxin: Steady-state plasma digoxin concentrations increased by approximately 20% when coadministered with atorvastatin.
  • Erythromycin: Plasma concentrations of atorvastatin increased approximately 40% with coadministration of erythromycin.

Contraindications

Hypersensitivity to any component, active liver disease, unexplained elevations of serum transaminases, and history of serious adverse reactions to HMG-CoA reductase inhibitors.

SideEffects

  • Constipation
  • Flatulence
  • Dyspepsia
  • Abdominal pain
  • Infection
  • Headache
  • Back pain
  • Rash
  • Asthenia
  • Arthralgia
  • Myalgia

PregnancyAndLactation

  • Pregnancy: Contraindicated during pregnancy due to potential adverse effects on fetal development.
  • Lactation: Not recommended for breastfeeding mothers due to potential adverse reactions in infants.

PrecautionsAndWarnings

Liver function tests should be performed before initiation and periodically thereafter. Discontinue therapy if markedly elevated CPK levels occur or myopathy is diagnosed or suspected.

SpecialPopulations

  • Geriatric: Plasma concentrations are higher in healthy elderly subjects compared to young adults, with a greater degree of LDL-lowering observed.
  • Pediatric: Pharmacokinetic data in the pediatric population are not available.
  • Gender: No clinically significant difference in LDL-C reduction with Liptor between men and women.
  • RenalInsufficiency: No influence on plasma concentrations or LDL-C reduction; dose adjustment is not necessary.
  • Hemodialysis: Not expected to significantly enhance clearance of Liptor due to extensive plasma protein binding.
  • HepaticInsufficiency: Markedly increased plasma concentrations in patients with chronic alcoholic liver disease.

OverdoseEffects

Specific treatment is not available for atorvastatin overdose. Symptomatic and supportive measures should be instituted.

TherapeuticClass

  • Other Anti-anginal & Anti-ischaemic drugs
  • Statins

StorageConditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

ChemicalStructure

  • MolecularFormula: C33H35FN2O5
  • ChemicalStructureImageURL: https://medex.com.bd/storage/res/g-res-92-atorvastatin-calcium-chemical-structure-vKDE8RIA4syu8MLTgdLW.svg

CommonQuestions

  • How should I take Liptor 40 mg Tablet?
  • What are the Side Effects of Liptor 40 mg Tablet?
  • Is Liptor 40 mg Tablet used for lowering cholesterol?
  • For how long do I need to take Liptor 40 mg Tablet? Is it safe for long-term use?
  • Does Liptor 40 mg Tablet cause memory loss?
  • Can Liptor 40 mg Tablet be prescribed to children?
  • Quick Tips: In general, Liptor 40 mg Tablet is safe. It may cause diarrhea, gas or an upset stomach. If any of these happen to you, take it with food.

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