Tabrex 500 mg (Tablet)
Unit Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Azithromycin dihydrate |
| Company | Aztec pharmaceuticals ltd |
Title
- Tabrex 500 mg Tablet
Categories
- Medicine
- Antibiotic
- Macrolide
- Infection Treatment
Indications
- Lower respiratory tract infections
- Upper respiratory tract infections
- Otitis media
- Skin and soft tissue infections
- Non-gonococcal urethritis
- Cervicitis due to Chlamydia trachomatis
Pharmacology
- Acid-stable
- Oral absorption
- High concentration in phagocytes
- Binding to 50S ribosomal subunit
- Interference with microbial protein synthesis
- Nucleic acid synthesis not affected
Dosage
- 500 mg once daily orally for 3 days (Adult)
- 1 gm as a single dose or 500 mg once on day 1, followed by 250 mg once daily for next 2 days (Adult - Chlamydia trachomatis)
- 10 mg/kg body weight once daily for 3 days (Children over 6 months)
- 500 mg once daily for 7-10 days in typhoid fever (Children)
Administration
- Reconstitution procedure of suspension
- Take at least 1 hour before or 2 hours after a meal
Interaction
- Antacid - take at least 1 hour before or 2 hours after
- Cyclosporin - caution with potential interactions
- Digoxin - monitor digoxin levels
- Ergot derivatives - should not be co-administered
- Methylprednisolone - no significant effect observed
- Theophylline - no evidence of pharmacokinetic interaction
- Warfarin - may be co-administered, monitor prothrombin time
- Terfenadine - did not affect pharmacokinetics, no significant changes in cardiac repolarization
Contraindications
- Hypersensitivity to Azithromycin or macrolide antibiotic
- Co-administration with ergot derivatives
- Patients with hepatic diseases
Side Effects
- Gastrointestinal side-effects (nausea, abdominal discomfort, vomiting, flatulence, diarrhea)
- Allergic reactions (rash, photosensitivity)
- Reversible elevations in liver transaminases
- Rare cases of cholestatic jaundice
- Transient mild reductions in neutrophil counts
- Reversible hearing impairment with higher doses for prolonged periods
Pregnancy & Lactation
- Category B
- No evidence of harm to fetus in animal studies
- Use during pregnancy only if adequate alternatives are not available
- Caution in administration to nursing women
Precautions & Warnings
- Rare serious allergic reactions reported
- Caution in patients with renal impairment (creatinine clearance >40 ml/min)
- Should not be used in patients with hepatic disease
- No evidence of effect on ability to drive or operate machinery
Overdose Effects
- Typical symptoms include hearing loss, severe nausea, vomiting, and diarrhea
- Indicated treatments include gastric lavage and general supportive measures
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C38H72N2O12