Tabrex 500 mg (Tablet)

Unit Price: ৳ 30.00

Medicine Details

Category Details
Generic Azithromycin dihydrate
Company Aztec pharmaceuticals ltd

Title

  • Tabrex 500 mg Tablet

Categories

  • Medicine
  • Antibiotic
  • Macrolide
  • Infection Treatment

Indications

  • Lower respiratory tract infections
  • Upper respiratory tract infections
  • Otitis media
  • Skin and soft tissue infections
  • Non-gonococcal urethritis
  • Cervicitis due to Chlamydia trachomatis

Pharmacology

  • Acid-stable
  • Oral absorption
  • High concentration in phagocytes
  • Binding to 50S ribosomal subunit
  • Interference with microbial protein synthesis
  • Nucleic acid synthesis not affected

Dosage

  • 500 mg once daily orally for 3 days (Adult)
  • 1 gm as a single dose or 500 mg once on day 1, followed by 250 mg once daily for next 2 days (Adult - Chlamydia trachomatis)
  • 10 mg/kg body weight once daily for 3 days (Children over 6 months)
  • 500 mg once daily for 7-10 days in typhoid fever (Children)

Administration

  • Reconstitution procedure of suspension
  • Take at least 1 hour before or 2 hours after a meal

Interaction

  • Antacid - take at least 1 hour before or 2 hours after
  • Cyclosporin - caution with potential interactions
  • Digoxin - monitor digoxin levels
  • Ergot derivatives - should not be co-administered
  • Methylprednisolone - no significant effect observed
  • Theophylline - no evidence of pharmacokinetic interaction
  • Warfarin - may be co-administered, monitor prothrombin time
  • Terfenadine - did not affect pharmacokinetics, no significant changes in cardiac repolarization

Contraindications

  • Hypersensitivity to Azithromycin or macrolide antibiotic
  • Co-administration with ergot derivatives
  • Patients with hepatic diseases

Side Effects

  • Gastrointestinal side-effects (nausea, abdominal discomfort, vomiting, flatulence, diarrhea)
  • Allergic reactions (rash, photosensitivity)
  • Reversible elevations in liver transaminases
  • Rare cases of cholestatic jaundice
  • Transient mild reductions in neutrophil counts
  • Reversible hearing impairment with higher doses for prolonged periods

Pregnancy & Lactation

  • Category B
  • No evidence of harm to fetus in animal studies
  • Use during pregnancy only if adequate alternatives are not available
  • Caution in administration to nursing women

Precautions & Warnings

  • Rare serious allergic reactions reported
  • Caution in patients with renal impairment (creatinine clearance >40 ml/min)
  • Should not be used in patients with hepatic disease
  • No evidence of effect on ability to drive or operate machinery

Overdose Effects

  • Typical symptoms include hearing loss, severe nausea, vomiting, and diarrhea
  • Indicated treatments include gastric lavage and general supportive measures

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C38H72N2O12

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