Zixin 500 mg (Tablet)

Unit Price: ৳ 45.00 (1 x 7: ৳ 315.00)
Strip Price: ৳ 315.00

Medicine Details

Category Details
Generic Azithromycin dihydrate
Company Osl pharma limited
Also available as
Zixin 200 mg suspension

Title

  • Zixin 500 mg Tablet

Categories

  • Antibiotic
  • Medication
  • Pharmaceutical

Description

  • Zixin is indicated for infections in lower respiratory tract, upper respiratory tract, otitis media, and skin and soft tissue infections
  • It is also used in the treatment of sexually transmitted diseases caused by Chlamydia trachomatis

Dosage

  • Oral:
    • 500 mg once daily orally for 3 days in adults
    • 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days in adults
    • 1 gm given as a single dose or 500 mg once on day 1, followed by 250 mg once daily for next 2 days in adults for sexually transmitted diseases caused by Chlamydia trachomatis
    • Various dosage options for children based on weight and indication
    • 500 mg as a single daily dose by the intravenous route for at least two days in adults for community-acquired pneumonia

Mode of Action

  • Azithromycin prevents the synthesis of essential proteins required by bacteria to carry out vital functions

Pharmacology

  • Absorption: Readily absorbed with greater absorption on an empty stomach
  • Time to Peak Concentration: 2.1 to 3.2 hours for oral dosage forms in adults
  • Phagocytes Concentration: High concentration in phagocytes, actively transported to the site of infection

Microbiology

  • Activeness Against:
    • Staphylococcus aureus
    • Streptococcus pneumoniae
    • Haemophilus influenzae
    • Neisseria gonorrhoeae
    • Chlamydia pneumoniae
    • Mycoplasma pneumoniae
    • Bordetella pertussis
    • Legionella pneumophila
    • Peptostreptococcus species
    • Prevotella bivia

Administration

  • Reconstitution Procedure:
    • Shake the bottle well to loosen the powder
    • Add boiled and cooled water up to the water mark of the bottle label
    • Shake until powder is completely mixed with water
  • Timing: Azithromycin should be taken at least 1 hour before or 2 hours after meal

Interaction

  • Antacid: Zixin should be taken at least 1 hour before or 2 hours after antacids
  • Carbamazepine: No significant effect observed on the plasma levels
  • Cyclosporin: Caution should be exercised before co-administration
  • Digoxin: Possibility of raised digoxin levels should be borne in mind
  • Ergot Derivatives: Should not be co-administered
  • Methylprednisolone: No significant effect on the pharmacokinetics
  • Theophylline: No evidence of pharmacokinetic interaction
  • Warfarin: Did not alter the anticoagulant effect of warfarin

Contraindications

  • Hypersensitivity to Azithromycin or any other macrolide antibiotic
  • Co-administration of ergot derivatives
  • Patients with hepatic diseases

Side Effects

  • Majority: Gastrointestinal in origin
  • Commonly Observed:
    • Nausea
    • Abdominal discomfort
    • Vomiting
    • Flatulence
    • Diarrhea
    • Loose stools
  • Allergic Reactions: Rash or photosensitivity
  • Rare Reports: Serious hypersensitivity reactions, reversible elevations in liver transaminases

Pregnancy & Lactation

  • Category: B
  • Evidence: Demonstrated no harm to fetus in animal reproduction studies, caution should be exercised during pregnancy
  • Breastfeeding: Caution should be exercised

Precautions & Warnings

  • Rare serious allergic reactions reported
  • Caution should be exercised in patients with renal impairment, severe hepatic impairment

Use in Special Populations

  • Renal Impairment: No dose adjustment needed in patients with mild renal impairment, caution should be exercised in patients with severe renal impairment
  • Hepatic Impairment: Should not be used in patients with hepatic disease
  • Effects on Ability: No evidence to suggest that it may have an effect on a patient’s ability to drive or operate machinery

Overdose Effects

  • Typical symptoms include hearing loss, severe nausea, vomiting, and diarrhea
  • Gastric lavage and general supportive measures are indicated

Storage Conditions

Keep in a dry place away from light and heat, keep out of the reach of children

Chemical Structure

  • Molecular Formula: C38H72N2O12
  • Image: https://medex.com.bd/storage/res/g-res-100-azithromycin-dihydrate-chemical-structure-tFo4BQqfsRzQwcODCGo2.svg

Commonly Asked Questions

  • What is Zixin 500 mg Tablet?: Performs its action by preventing the synthesis of essential proteins required by bacteria
  • Uses: Treatment and prevention of community-acquired pneumonia, pharyngitis/tonsillitis, and skin and soft tissue infections
  • Side Effects:
    • Diarrhea
    • Dry or scaly skin
    • Abdominal pain
    • Difficult or painful urination
    • Vomiting
    • Fever
    • Acid or sour stomach
    • Aggression or anger
    • Excessive air or gas in the stomach
    • Heartburn
  • Storage and Disposal: Keep in a cool dry place and its original packaging, consult a doctor for further uses
  • Can the use of Zixin 500 mg Tablet cause diarrhea?: Yes, it can cause diarrhea due to its impact on helpful bacteria in the stomach or intestine
  • Is Zixin 500 mg Tablet safe?: It is safe if used at prescribed doses as advised by a doctor
  • Is Zixin 500 mg Tablet an antibiotic?: Yes, it belongs to a class of antibiotics known as macrolides
  • What if I don't get better even after taking Zixin 500 mg Tablet?: Inform your doctor if no improvement is noticed after 3 days of taking Zixin 500 mg Tablet

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