Betaloc 50 mg (Tablet)

Indications

• Hypertension management
• Angina pectoris management
• Cardiac arrhythmias treatment
• Hyperthyroidism adjunct treatment
• Pain relief in myocardial infarction
• Reduction of mortality in acute myocardial infarction

Pharmacology

• Selective beta1-blocker
• Reduction of heart rate
• Inhibition of catecholamines' effect on the heart
• Less interference with insulin release and carbohydrate metabolism
• Less interference with cardiovascular response to hypoglycemia

Dosage & Administration

• Total daily dosage range of 100-400 mg
• Twice-daily dose for hypertension if full control not achieved with a single daily dose
• Various dosages for different conditions such as angina, cardiac arrhythmias, hyperthyroidism, and myocardial infarction
• Initial and maintenance dosage for extended-release tablets
• Intravenous injection dosage for arrhythmias, surgery, and myocardial infarction

Interaction

• Additive effect with catecholamine-depleting drugs
• Increase in concentration with CYP2D6 inhibiting drugs
• Increased risk of bradycardia with concomitant use of digitalis glycosides and beta-blockers
• Exacerbation of rebound hypertension with clonidine withdrawal

Contraindications

• AV block
• Uncontrolled heart failure
• Severe bradycardia
• Sick-sinus syndrome
• Cardiogenic shock
• Severe peripheral arterial disease
• Hypersensitivity to Metoprolol or other Beta-blockers

Side Effects

• Tiredness
• Dizziness
• Depression
• Diarrhea
• Itching or rash
• Shortness of breath
• Slow heart rate
• Mental confusion
• Headache
• Somnolence
• Nausea
• Dry mouth
• Blurred vision
• Decreased libido
• Tinnitus
• Intensification of AV block

Pregnancy & Lactation

• Pregnancy Category C
• Caution in use during pregnancy
• Excretion in breast milk in small quantities
• Caution in use during lactation

Precautions & Warnings

• Caution in bronchospastic diseases
• Controversy over withdrawing beta-blocking therapy prior to major surgery
• Masking of tachycardia occurring with hypoglycemia
• Precipitation or aggravation of symptoms of arterial insufficiency in patients with peripheral vascular disease
• Caution in use with calcium channel blockers

Use in Special Populations

• Caution in use with impaired hepatic function
• Similar adverse event profile for pediatric patients aged 6 to 16 years as compared with adult patients
• Safety and effectiveness not established in patients <6 years of age
• No notable differences in efficacy or adverse events between older and younger patients

Overdose Effects

• Manifestations such as hypotension, bradycardia, atrioventricular block, heart failure, cardiogenic shock, and others
• Close monitoring and treatment of cardiovascular, respiratory, and renal function
• Prevention of further absorption by induction of vomiting, gastric lavage, or administration of activated charcoal if ingestion is recent
• Treatment of cardiovascular complications via sympathomimetic agents, atropine, inotropic agents, and temporary pacing if required

Storage Conditions

• Cool and dry place
• Protected from light

Related Brands

• Betaloc 25 mg (Tablet) - drug-international-ltd
• Betacard 50 mg (Tablet) - aristopharma-ltd