Betaloc-XR 50 mg (Tablet (Extended Release))

Title

• Betaloc-XR extended-release metoprolol tablets

Categories

• Medicine
• Pharmaceuticals
• Cardiovascular medication

Indications

• Management of hypertension and angina pectoris
• Treatment of cardiac arrhythmias
• Adjunct treatment of hyperthyroidism
• Reducing infarct size in acute myocardial infarction
• Pain relief and decreased need for opiate analgesics
• Reduction of mortality in acute myocardial infarction patients

Mode of Action

• Selective beta1-blocker
• Reduces or inhibits the agonistic effect on the heart of catecholamines
• Reduces heart rate, cardiac output, cardiac contractility, and blood pressure
• Interferes less with insulin release and carbohydrate metabolism
• Interferes much less with the cardiovascular response to hypoglycemia

Dosage & Administration

• Total daily dosage Metoprolol 100-400 mg for hypertension
• Metoprolol 50-100 mg for angina pectoris
• Maintenance dose of 200 mg daily for myocardial infarction
• Initial dosage of 25-100 mg for extended-release tablets

Interaction

• Additive effect with catecholamine‐depleting drugs
• Increased concentration with CYP2D6 inhibiting drugs
• Increased risk of bradycardia with concomitant use of digitalis glycosides
• Exacerbation of rebound hypertension when clonidine is withdrawn

Contraindications

• AV block
• Uncontrolled heart failure
• Severe bradycardia
• Sick-sinus syndrome
• Cardiogenic shock
• Severe peripheral arterial disease
• Known hypersensitivity to Metoprolol or other B-blockers

Side Effects

• Tiredness
• Dizziness
• Depression
• Diarrhea
• Shortness of breath
• Slow heart rate
• Mental confusion
• Headache
• Nausea
• Insomnia
• Blurred vision
• Decreased libido
• Tinnitus
• Intensification of AV block

Pregnancy & Lactation

• Pregnancy Category C
• Excretion in breast milk in very small quantities

Precautions & Warnings

• Caution in patients with bronchospastic disease
• Controversy regarding withdrawing beta‐blocking therapy prior to major surgery
• Masking of tachycardia occurring with hypoglycemia
• Aggravation of symptoms of arterial insufficiency in peripheral vascular disease patients

Use in Special Populations

• Caution in patients with impaired hepatic function
• No clinically relevant differences in pediatric patients aged 6 to 16 years
• No notable differences in efficacy or adverse events between older and younger patients

Overdose Effects

• Severe hypotension
• Sinus bradycardia
• Atrioventricular block
• Cardiogenic shock
• Bronchospasm
• Impairment of consciousness
• Coma
• Nausea
• Vomiting
• Cyanosis
• Hypoglycemia
• Hyperkalemia

Storage Conditions

• Store in a cool, dry place, protected from light

Related Brands

• Betaloc 50 mg (Tablet) - drug-international-ltd
• Betaloc 25 mg (Tablet) - drug-international-ltd
• Betacard 50 mg (Tablet) - aristopharma-ltd