Betaloc-XR 100 mg (Tablet (Extended Release))

Indications

• Management of hypertension and angina pectoris
• Treatment of cardiac arrhythmias
• Adjunct to the treatment of hyperthyroidism
• Early intervention in acute myocardial infarction
• Pain relief to decrease the need for opiate analgesics
• Reduction of mortality in acute myocardial infarction

Pharmacology

• Selective beta1-blocker
• Reduction or inhibition of the agonistic effect on the heart of catecholamines
• Reduction in heart rate, cardiac output, cardiac contractility, and blood pressure
• Less interference with insulin release and carbohydrate metabolism
• Less interference with the cardiovascular response to hypoglycemia

Dosage & Administration

• Dosage range for hypertension: 100-400 mg daily
• Starting dose for hypertension: 100 mg daily
• Individualized dosage for angina pectoris
• Dosage for cardiac arrhythmias control: 50-300 mg daily
• Dosage for hyperthyroidism: 50 mg four times a day
• Oral therapy for myocardial infarction: 50 mg every 6 hours for 48 hours

Interaction

• Additive effect with catecholamine‐depleting drugs
• Increased concentration with CYP2D6 inhibitors
• Risk of bradycardia with concomitant use of digitalis glycosides
• Exacerbation of rebound hypertension with withdrawal of clonidine

Contraindications

• AV block
• Uncontrolled heart failure
• Severe bradycardia
• Sick-sinus syndrome
• Cardiogenic shock
• Severe peripheral arterial disease

Side Effects

• Tiredness
• Dizziness
• Depression
• Diarrhea
• Itching or rash
• Shortness of breath
• Slow heart rate
• Mental confusion
• Headache
• Somnolence
• Nightmares
• Insomnia
• Dyspnea
• Nausea
• Dry mouth
• Gastric pain
• Constipation
• Flatulence
• Heartburn
• Pruritus
• Musculoskeletal pain
• Blurred vision
• Decreased libido
• Tinnitus
• Intensification of AV block

Pregnancy & Lactation

• Pregnancy Category C
• Excretion in breast milk in very small quantities
• Caution in administration to nursing women

Precautions & Warnings

• Use with caution in patients with bronchospastic disease
• Controversy regarding withdrawal prior to major surgery
• Masking of tachycardia occurring with hypoglycemia
• Precipitation or aggravation of symptoms of arterial insufficiency
• Caution in patients treated with calcium channel blockers concomitantly

Use in Special Populations

• Caution in patients with impaired hepatic function
• No clinically relevant differences in adverse event profile for pediatric patients aged 6 to 16 years
• Safety and effectiveness not established in patients <6 years of age
• No notable differences in efficacy or rate of adverse events between older and younger patients

Overdose Effects

• Possible severe hypotension
• Sinus bradycardia
• Atrioventricular block
• Heart failure
• Cardiogenic shock
• Cardiac arrest
• Bronchospasm
• Impairment of consciousness
• Coma
• Nausea
• Vomiting
• Cyanosis
• Hypoglycemia
• Hyperkalemia

Storage Conditions

• Store in a cool and dry place
• Protected from light

Related Brands

• Betacard 50 mg (Tablet) - aristopharma-ltd
• Betaloc 25 mg (Tablet) - drug-international-ltd
• Betaloc 50 mg (Tablet) - drug-international-ltd
• Betaloc-XR 50 mg (Tablet (Extended Release)) - drug-international-ltd