Lopresor 50 mg (Tablet)
Unit Price: ৳ 1.30 (100's pack: ৳ 130.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metoprolol tartrate |
| Company | Bristol pharmaceuticals ltd |
Indications
- Management of hypertension
- Management of angina pectoris
- Cardiac arrhythmias
- Adjunct to the treatment of hyperthyroidism
- Management of acute myocardial infarction
- Pain relief
Pharmacology
- Selective beta1-blocker
- Reduces heart rate
- Reduces cardiac output
- Reduces cardiac contractility
- Reduces blood pressure
- Interferes less with insulin release
- Interferes less with carbohydrate metabolism
- Interferes less with cardiovascular response to hypoglycemia
Dosage & Administration
- Film-coated tablet
- Extended-release tablet
- IV Injection
- Individualized dosage for different conditions
- Dosing for hypertension, angina pectoris, cardiac arrhythmias, hyperthyroidism, myocardial infarction, heart failure, and arrhythmias in surgery
- Dosage adjustments for elderly and hepatically impaired patients
Interaction
- Catecholamine‐depleting drugs
- CYP2D6 inhibiting drugs
- Concomitant use of digitalis glycosides
- Rebound hypertension with clonidine withdrawal
Contraindications
- AV block
- Uncontrolled heart failure
- Severe bradycardia
- Sick-sinus syndrome
- Cardiogenic shock
- Severe peripheral arterial disease
- Known hypersensitivity to Metoprolol or other B-blockers
Side Effects
- Tiredness
- Dizziness
- Depression
- Diarrhea
- Itching or rash
- Shortness of breath
- Slow heart rate
- Mental confusion
- Headache
- Somnolence
- Nightmares
- Insomnia
- Dyspnea
- Nausea
- Dry mouth
- Gastric pain
- Constipation
- Flatulence
- Digestive tract disorders
- Heartburn
- Pruritus
- Musculoskeletal pain
- Blurred vision
- Decreased libido
- Tinnitus
- Intensification of AV block
Pregnancy & Lactation
- Pregnancy Category C
- Excretion in breast milk
- Caution during nursing
Precautions & Warnings
- Use with caution in patients with bronchospastic disease
- Controversy over withdrawing beta‐blocking therapy prior to major surgery
- Masking of tachycardia during hypoglycemia
- Aggravation of arterial insufficiency in patients with peripheral vascular disease
- Caution with calcium channel blockers
Use in Special Populations
- Use with caution in patients with impaired hepatic function
- Safety and effectiveness for pediatric use
- Efficacy and adverse events in older vs. younger patients
Overdose Effects
- Severe hypotension
- Sinus bradycardia
- Atrioventricular block
- Heart failure
- Cardiogenic shock
- Cardiac arrest
- Bronchospasm
- Impairment of consciousness
- Coma
- Nausea
- Vomiting
- Cyanosis
- Hypoglycemia
- Hyperkalemia
Storage Conditions
- Cool and dry place
- Protected from light