Acubis 2.5 mg (Tablet)

Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Bisoprolol hemifumarate
Company Concord pharmaceuticals ltd
Also available as
Acubis 5 mg tablet

Title

Acubis 2.5 mg Tablet

Categories

  • Medicine
  • Pharmaceutical

Description

Beta-blocker medication for hypertension, angina, and heart failure

Dosage and administration

Adult starting dose 5 mg once daily, may increase to 10-20 mg. No established safety and effectiveness in children. Caution in patients with renal or hepatic impairment.

Pharmacology

  • Mode of action: Selectively blocks ß1 adrenergic receptor in the heart and vascular smooth muscle
  • Absorption and bioavailability: Bisoprolol is almost completely absorbed (>90%) from the gastrointestinal tract. Absolute bioavailability of 88%, unaffected by food intake.
  • Metabolism: Metabolized via oxidative pathways with no subsequent conjugation. Primarily metabolized via CYPSA4 (-95%) with CYP2D6 having only a minor role.
  • Elimination: Balanced between renal elimination and hepatic metabolism, clearance approximately 15 L/h, elimination half-life of 10-12 hours.

Interaction

  • Other beta blocking agents: Should not be combined with other β-blocking agents.
  • Catecholamine depleting drugs: Patients receiving catecholamine-depleting drugs should be monitored closely.
  • Centrally active antihypertensive agents: β-blockers may exacerbate rebound hypertension following withdrawal of clonidine.
  • Antiarrhythmic agents: Should be used with care when myocardial depressants or inhibitors of A-V conduction are used concurrently.
  • Calcium channel blockers: Combined use with calcium channel blockers can lead to prolongation of S-A and A-V conduction.

Indications

  • Hypertension
  • Angina
  • Moderate to severe heart failure

Contraindications

  • Cardiogenic shock
  • Overt heart failure
  • Second or third degree A-V block
  • Right ventricular failure secondary to pulmonary hypertension
  • Sinus bradycardia

Side effects

  • Fatigue
  • Dizziness
  • Headache
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Abdominal pain
  • Cold or numb extremities
  • Muscle weakness or cramps
  • Breathing difficulties
  • Bronchospasm

Pregnancy and lactation

  • Pregnancy: Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
  • Lactation: Not known if excreted in human milk. Mothers should stop nursing if use is considered essential.

Precautions and warnings

  • Impaired renal or hepatic function
  • Patients with history of severe anaphylactic reaction may be more reactive to allergens

Therapeutic class

Anti adrenergic agent (Beta blockers), Beta-adrenoceptor blocking drugs

Storage conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Chemical structure

  • Molecular formula: C18H31NO4
  • Chemical structure image url: https://medex.com.bd/storage/res/g-res-135-bisoprolol-hemifumarate-chemical-structure-rpXCAgy2GIOFKWUs5Peu.svg

Common questions and answers

  • What is Acubis 2.5 mg Tablet?
  • What is Acubis 2.5 mg Tablet used for?
  • How should I take Acubis 2.5 mg Tablet?
  • What are the side effects of Acubis 2.5 mg Tablet?
  • Is Acubis 2.5 mg Tablet safe to take?
  • Should I use Acubis 2.5 mg Tablet empty stomach, before food or after food?
  • What are the instructions for the storage and disposal of Acubis 2.5 mg Tablet?
  • Quick Tips: May cause dizziness, Can hide symptoms of low blood sugar, Do not stop suddenly

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