Bisten 5 mg (Tablet)

Unit Price: ৳ 9.00 (30's pack: ৳ 270.00)

Medicine Details

Category Details
Generic Bisoprolol hemifumarate
Company Edruc limited
Also available as
Bisten 25 mg tablet Bisten 10 mg tablet

Title

Bisten 5 mg Tablet

Categories

  • Hypertension
  • Angina
  • Heart Failure
  • Beta Blocker
  • Anti-Adrenergic Agent
  • Pharmacology

Description

  • Indications:
    • Hypertension
    • Angina
    • Moderate to Severe Heart Failure
  • Pharmacology:
    • Selective ß1 blocker
    • Reduces heart rate
    • Decreases arterial hypertension
    • Low inter and intra-individual variability of plasma concentration profiles
    • Almost completely absorbed from gastrointestinal tract
    • Extensively distributed
    • Metabolized via oxidative pathways with no subsequent conjugation
    • Balanced clearance between renal elimination and hepatic metabolism
    • Elimination half-life of 10-12 hours
  • Dosage & Administration:
    • Usual starting dose of 5 mg once daily for mild to moderate hypertension
    • Increase to 10 mg and then to 20 mg once daily if necessary
    • Appropriate interval for dose titration is 2 weeks
    • Safety and effectiveness in children not established
    • Initial daily dose of 5 mg in patients with hepatic or renal impairment
    • No need to adjust the dose in elderly unless significant renal or hepatic dysfunction
  • Interaction:
    • Not to be combined with other β-blocking agents
    • Closely monitor patients receiving catecholamine-depleting drugs
    • May exacerbate rebound hypertension when coadministered with clonidine
    • Use with care when myocardial depressants or inhibitors of A-V conduction are used concurrently
    • Combined use with calcium channel blockers can lead to severe hypotension, bradycardia, and cardiac failure
  • Contraindications:
    • Cardiogenic shock
    • Overt heart failure
    • Second or third degree A-V block
    • Right ventricular failure secondary to pulmonary hypertension
    • Sinus bradycardia
  • Side Effects:
    • Fatigue
    • Dizziness
    • Headache
    • Disturbances of the gut
    • Cold or numb extremities
    • Muscle weakness or cramps
    • Breathing difficulties due to a narrowing of the airways
  • Pregnancy & Lactation:
    • Not teratogenic in rats at doses up to 150 mg/kg/day
    • Fetotoxic at 50 mg/kg/day and maternotoxic at 150 mg/kg/day
    • No studies in pregnant women
    • Small amounts detected in the milk of lactating rats
    • Consider essential use during lactation and stop nursing if necessary
  • Precautions & Warnings:
    • Use caution in adjusting the dose in patients with renal or hepatic impairment
    • Patients with a history of severe anaphylactic reaction may be more reactive to allergens while taking beta-blockers
    • Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reactions
  • Therapeutic Class:
    • Beta-adrenoceptor blocking drugs
    • Beta-blockers
  • Storage Conditions:
    • Keep in a dry place away from light and heat
    • Keep out of the reach of children
  • Chemical Structure:
    • Molecular Formula: C18H31NO4

Attributes

  • Low inter and intra-individual variability of plasma concentration profiles
  • Almost completely absorbed from gastrointestinal tract
  • Extensively distributed
  • Metabolized via oxidative pathways with no subsequent conjugation
  • Balanced clearance between renal elimination and hepatic metabolism
  • Elimination half-life of 10-12 hours
  • Increased late resorptions in rats at high doses
  • Increased early resorptions in rabbits at high doses
  • Selective ß1 blocker
  • Reduces heart rate
  • Decreases arterial hypertension
  • Usual starting dose of 5 mg once daily for mild to moderate hypertension
  • Increase to 10 mg and then to 20 mg once daily if necessary
  • Appropriate interval for dose titration is 2 weeks
  • Not teratogenic in rats at doses up to 150 mg/kg/day
  • Closely monitor patients with renal or hepatic impairment
  • Use caution in adjusting the dose in patients with renal or hepatic impairment
  • No need to adjust the dose in elderly unless significant renal or hepatic dysfunction
  • Not to be combined with other β-blocking agents
  • May exacerbate rebound hypertension when coadministered with clonidine
  • Use with care when myocardial depressants or inhibitors of A-V conduction are used concurrently
  • Combined use with calcium channel blockers can lead to severe hypotension, bradycardia, and cardiac failure
  • Cardiogenic shock
  • Overt heart failure
  • Second or third degree A-V block
  • Right ventricular failure secondary to pulmonary hypertension
  • Sinus bradycardia
  • Fatigue
  • Dizziness
  • Headache
  • Disturbances of the gut
  • Cold or numb extremities
  • Muscle weakness or cramps
  • Breathing difficulties due to a narrowing of the airways
  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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