Bisten 10 mg (Tablet)

Unit Price: ৳ 14.00 (20's pack: ৳ 280.00)

Medicine Details

Category Details
Generic Bisoprolol hemifumarate
Company Edruc limited
Also available as
Bisten 25 mg tablet Bisten 5 mg tablet

Indications

  • Hypertension
  • Angina
  • Moderate to severe heart failure

Pharmacology

  • High level of affinity for the ß1 receptor
  • Reduces heart rate and cardiac output
  • No change in cholesterol fraction
  • Bioavailability of 88%
  • Metabolized via oxidative pathways
  • Renally eliminated metabolites
  • Primary metabolism via CYPSA4
  • Elimination half-life of 10-12 hours

Dosage & Administration

  • Usual starting dose of 5 mg once daily
  • Dose titration interval of 2 weeks
  • Dose adjustment for renal or hepatic impairment
  • No established safety and effectiveness in children
  • No usual dose adjustment in elderly patients

Interaction

  • Not to be combined with other β-blocking agents
  • Close monitoring with catecholamine-depleting drugs
  • Exacerbation with centrally active antihypertensive agents
  • Used with care when myocardial depressants or inhibitors of A-V conduction are used concurrently
  • Combined use with calcium channel blockers can lead to severe hypotension, bradycardia and cardiac failure

Contraindications

  • Cardiogenic shock
  • Overt heart failure
  • Second or third degree A-V block
  • Right ventricular failure secondary to pulmonary hypertension
  • Sinus bradycardia

Side Effects

  • Fatigue
  • Dizziness
  • Headache
  • Disturbances of the gut
  • Cold or numb extremities
  • Muscle weakness or cramps
  • Breathing difficulties
  • Bronchospasm in people with asthma or COPD

Pregnancy & Lactation

  • Fetotoxic and maternotoxic effects observed in animal studies
  • Use only if potential benefit justifies the potential risk to the fetus
  • Small amounts detected in the milk of lactating rats
  • Unknown excretion in human milk

Precautions & Warnings

  • Caution in adjusting the dose in patients with renal or hepatic impairment
  • Patients with a history of severe anaphylactic reaction may be more reactive to allergens
  • Unresponsive to the usual doses of epinephrine used to treat allergic reactions

Therapeutic Class

  • Anti adrenergic agent (Beta blockers)
  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula : C18H31NO4
  • Chemical Structure Image URL : https://medex.com.bd/storage/res/g-res-135-bisoprolol-hemifumarate-chemical-structure-rpXCAgy2GIOFKWUs5Peu.svg

Common Questions about Bisten 10 mg Tablet

  • Beta-blocker medication
  • Lower blood pressure, reduce workload on the heart, prevent chest pain
  • Oral administration once daily with or without food
  • Side effects include dizziness, fatigue, headache, breathing difficulties, and cold hands and feet
  • Generally safe to take, but consult a doctor with existing health conditions
  • To be taken after food in prescribed dosage
  • Keep in a cool dry place and in its original packaging. Make sure it remains unreachable to children and pets

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