Orabis 2.5 mg (Tablet)

Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Bisoprolol hemifumarate
Company Ibn sina pharmaceuticals ltd
Also available as
Orabis 5 mg tablet

Indications

  • Hypertension
  • Angina
  • Moderate to severe heart failure

Pharmacology

  • Selective ß1 blocker
  • Reduces heart rate
  • Reduces cardiac output
  • Decreases arterial hypertension
  • Impacts lipid metabolism
  • High absorption rate
  • Small first-pass effect
  • Bioavailability of 88%
  • Metabolized via oxidative pathways
  • Renally eliminated metabolites
  • Majorly metabolized via CYPSA4
  • Balanced renal and hepatic elimination
  • Elimination half-life of 10-12 hours

Dosage & Administration

  • Usual starting dose of 5 mg once daily
  • May be increased to 10 mg or 20 mg once daily
  • Appropriate interval for dose titration is 2 weeks
  • Safety and effectiveness in children not established
  • Initial daily dose in patients with hepatic or renal impairment is 5 mg
  • Dose adjustment caution in patients with impaired renal or hepatic function
  • No need for dose adjustment in geriatric patients

Interaction

  • Not recommended for combination with other β-blocking agents
  • Monitor closely when combined with catecholamine-depleting drugs
  • Caution when combined with centrally active antihypertensive agents
  • Use with care when myocardial depressants or inhibitors of A-V conduction are used concurrently
  • Combined use with calcium channel blockers with negative inotropic effects can lead to severe hypotension

Contraindications

  • Cardiogenic shock
  • Overt heart failure
  • Second or third degree A-V block
  • Right ventricular failure secondary to pulmonary hypertension
  • Sinus bradycardia

Side Effects

  • Fatigue
  • Dizziness
  • Headache
  • Disturbances of the gut
  • Cold or numb extremities
  • Muscle weakness or cramps
  • Breathing difficulties due to bronchospasm in people with asthma or COPD

Pregnancy & Lactation

  • Not teratogenic in rats at doses up to 150 mg/kg/day
  • Fetotoxic and maternotoxic effects observed in rats at higher doses
  • No studies in pregnant women
  • Small amounts excreted in the milk of lactating rats

Precautions & Warnings

  • Use caution in adjusting the dose in patients with renal or hepatic impairment
  • Patients with severe anaphylactic reaction history may be more reactive to repeated challenge
  • Unresponsive to usual doses of epinephrine used to treat allergic reactions

Therapeutic Class

  • Anti adrenergic agent (Beta blockers)
  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula : C<sub>18</sub>H<sub>31</sub>NO<sub>4</sub>

Common Questions about Orabis 2.5 mg Tablet

  • Orabis 2.5 mg Tablet is a beta-blocker medication
  • Used for High blood pressure (hypertension), Chest pain (angina), and Heart failure
  • Take by mouth, with or without food, once daily
  • Side effects include Dizziness, Fatigue, Headache, Slow heart rate, Difficulty breathing, and Cold hands and feet
  • Generally safe, but consult doctor if various health conditions are present
  • Take after food in prescribed dosage
  • Storage instructions and quick tips provided

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